Plasma 25-Hydroxyvitamin D, Vitamin D Binding血浆25羟维生素D、维生素D结合 蛋白质和结肠直肠癌的风险 护士健康研究

《Plasma 25-Hydroxyvitamin D, Vitamin D Binding血浆25羟维生素D、维生素D结合 蛋白质和结肠直肠癌的风险 护士健康研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、PublishedOnlineFirstMay31,2016;DOI:10.1158/1940-6207.CAPR-16-0053ResearchArticleCancerPreventionResearchPlasma25-HydroxyvitaminD,VitaminDBindingProtein,andRiskofColorectalCancerintheNurses'HealthStudy1,2,34,532MingyangSong,GaureeGuptaKonijeti,ChenYuan,AshwinN.

2、Ananthakrishnan,6,7,86,93,8,96ShujiOgino,CharlesS.Fuchs,EdwardL.Giovannucci,KimmieNg,and1,2,9,10AndrewT.ChanAbstractTotalcirculating25-hydroxyvitaminD[25(OH)D)]hasbeenDwasassociatedwithlowercolorectalcancerrisk(Pfortrend¼associatedwithlowerriskofcolorectalcanc

3、er.Thephysiologic0.01).Comparedwithwomeninthelowestquintileoftotal25mechanism,however,maybemoredirectlyrelatedtothefreeor(OH)D,thoseinthehighestquintilehadamultivariable-adjustedbioavailablefractionof25(OH)D,whichisinfluencedbylevelsofoddsratio(OR)forcolorectal

4、cancerof0.54[95%confidencevitaminDbindingprotein(VDBP).Weassessedtheassociationofinterval(CI),0.33–0.87].Comparingextremequintiles,wedidprediagnosistotal,free,andbioavailable25(OH)DandVDBPnotfindanysignificantassociationwithriskofcolorectalcancerwithcolorectalcan

5、cerriskamongpredominantlywhitewomeninforVDBP(OR,0.98;95%CI,0.65–1.47),free25(OH)D(OR,0.71;theNurses'HealthStudy(NHS)whoprovidedabloodspecimen95%CI,0.46–1.10),orbioavailable25(OH)D(OR,0.92;95%CI,in1989–1990.Wedocumented378casesofcolorectalcancer0.60–1.42).Incon

6、clusion,prediagnosislevelsoftotal,butnotthrough2011andmatchedthemto689controlsaccordingtoagefreeorbioavailable25(OH)D,wereassociatedwithlowercolo-andtimeofblooddraw.Wegenotypedtwocommonpolymorph-rectalcancerrisk.Althoughourfindingssupportaninverseismsinthegenec

7、odingVDBPandcalculatedfreeandbioavailableassociationofvitaminDwithcolorectalcancer,thisassociation25(OH)Dlevelsbasedontotal25(OH)D,VDBP,albumin,anddoesnotappeartobeduetotheunboundorbioavailablefractiontheirestimatedgenotype-specificbindingaffinities.Total25(OH)o

8、fcirculatingvitaminD.CancerPrevRes;9(8);664–72.Ó2016AACR.Introductionproperties,includingreductionofinflammation,suppressionofcellularproliferation,inductionofapoptosisanddifferenti