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1、ComparisonoftheRespiratoryMicrobiomeinHealthyNonsmokersandSmokersAlisonMorris1,2,JamesM.Beck3,4,5,PatrickD.Schloss3,ThomasB.Campbell5,KristinaCrothers6,JeffreyL.Curtis3,4,SoniaC.Flores5,AndrewP.Fontenot5,ElodieGhedin7,8,LaurenceHuang9,KathleenJablonski10,EricKlee
2、rup11,SusanV.Lynch9,EricaSodergren12,HomerTwigg13,VincentB.Young3,14,ChristineM.Bassis3,4,ArvindVenkataraman15,ThomasM.Schmidt15,andGeorgeM.Weinstock12;onbehalfoftheLungHIVMicrobiomeProject1278DepartmentofMedicine,DepartmentofImmunology,DepartmentofComputationala
3、ndSystemsBiology,andCenterforVaccineResearch,UniversityofPittsburgh,Pittsburgh,Pennsylvania;3DepartmentofInternalMedicineand14DepartmentofMicrobiologyandImmunology,Universityof45Michigan,AnnArbor,Michigan;VeteransAffairsAnnArborHealthcareSystem,AnnArbor,Michigan;
4、DepartmentofMedicine,UniversityofColorado69Denver,Aurora,Colorado;DepartmentofMedicine,UniversityofWashington,Seattle,Washington;DepartmentofMedicine,UniversityofCalifornia1011SanFrancisco,SanFrancisco,California;DepartmentofEpidemiologyandBiostatistics,GeorgeWas
5、hingtonUniversity,Washington,DC;Department12ofMedicine,UniversityofCaliforniaLosAngeles,LosAngeles,California;TheGenomeInstitute,WashingtonUniversitySchoolofMedicine,St.Louis,1315Missouri;DepartmentofMedicine,IndianaUniversity,Indianapolis,Indiana;andDepartmentof
6、MicrobiologyandMolecularGenetics,MichiganStateUniversity,EastLansing,MichiganRationale:Resultsfrom16SrDNA-encodinggenesequencebased,culture-independenttechniqueshaveledtoconflictingconclusionsATAGLANCECOMMENTARYaboutthecompositionofthelowerrespiratorytractmicrobio
7、me.Objectives:Tocomparethemicrobiomeoftheupperandlowerre-ScientificKnowledgeontheSubjectspiratorytractinhealthyHIV-uninfectednonsmokersandsmokersDefinitionofthehumanmicrobiomeisanareaofhighin-inamulticentercohort.terest,butstudiesofthelungmicrobiomeareatearlystages
8、.Methods:Participantswerenonsmokersandsmokerswithoutsignif-Culture-independenttechniqueshaveproducedconflictingicantcomorbidities.Oralwashesandbronchoscopicalve