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1、Chapter13Zoonoticbacteria1What’szoonosis?Zoonosis动物源性疾病adiseasethatcanbetransmittedfromanimalstohumansZoonoticbacteria动物源性细菌bacteriacausingzoonoses23What’reprimaryzoonoticbacteria?GeneraSourceofhumaninfectionDiseaseBrucellaspp.Pigs,cattle,goats,sheepBrucelosisYer
2、siniapestisRodentsPlagueBacillusantracisCattle,goats,sheep,horsesAnthrax4Brucella布鲁菌属5BrucellaB.abortus:cattleB.melitensis:goat,sheepB.suis:swineB.canis:dog6BiologicalpropertiesShapeandstructurecoccobacillus:0.4-0.8～0.5-1.5μmGram-negativeNonmotile,non-spore-formi
3、ngmicrocapsule(some)7BiologicalpropertiesCultivationObligateaerobes5-10%CO2(B.abortus)fastidiousslowgrowth:5～10d8BiologicalpropertiesResistancestrongresistance:drysensitivity:moistheatVUradiationinfectants9PathogenesisVirulencefactorendotoxin(main)invasiveness:ca
4、psule,enzymes10PathogenesisTransmissioncontactdigestivetractrespiratorytract11Transmission12PathogenesisDisease:brucelosis/undulantfever波浪热animals:abortioninfectionsofgenitalsystemsinapparentinfections(source)humans:undulantfeverorganism(asafacultativeintracellul
5、arparasite)→lymphaticsystem→blood（bacteremia）→liver,speen,bonemarrow,lymphnodes→bacteremia(undulantfever)13ImmunityCMIInfectionimmunitynoninfectionimmunity14ControlPreventionanimals:slaughterimmunizationpasteurizationhumans:novaccineavailableTreatmenttetracycline
6、,ampicillin15Yersinia耶尔森菌属16YersiniaSpeciesTransmissionDiseaseY.Pestis鼠疫耶尔森菌FleabiteRespiratorytractPlagueY.Enterocolitica小肠结肠炎耶尔森菌DigestivetractcontactEnterocolitisY.Pseudotuberculosis假结核耶尔森菌DigestivetractEnterocolitis17Y.EnterocoliticaVirulencefactorenterotoxin
7、,V-WantigenTransmissiondigestivetract(main),contactClinicaltypesinflammationofgastrointestineinflammationofterminalileum,appendix,andmesentericlymphnodesnodalerythemaandarthritissepticemia18Y.Pestis19BiologicalpropertiesShapeandstructure0.5-1.0～1-2μm,coccobacillu
8、sGram-negative,bipolarstainingcapsulenonmotilenon-spore-forming20BiologicalpropertiesCultivationfacultativeaerobesslowgrowthoptimumtemperature:27～30℃inbroth:st
