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1、ABSTRACTThispaperfirstdiscussestherelevantconcepts,hazardous,drugresistance,mechanismofdrugresistance,resistancecharacteristics,detectionmethodsandtheresearchstatusathomeandabroadonthestaphylococcusaureus.Andthenusingthegramstain,separationofculture,biochemicaltestsanddrugsensitivet
2、estmethods,tostudythepatientsofdifferentdepartmentsinYiChunpeople'shospital,theresultsshowthatthestatisticalresultsofStaphylococcusaureusinthetwentyninemonths,therewere714strainsofS.aureusisolated.Staphylococcusaureusmainlycomefromsputumsamples,accountedfor63.6%;accordingtothedistri
3、butionofdepartments,respiratorydepartmentofinternalmedicinehastheabsoluteadvantage,48.6%,andfollowedbydepartmentofneurosurgery,27.1%;506strainsofmethicillin-resistantStaphylococcusciureus^MRSA)weredetected.MRSAintheyearsJanuary2012〜May2014detectionrateshowedanincreasingtrendyearbyye
4、ar.Throughthesensitivetest,throughStaphylococcusaureusto15kindsofantibiotics,thatalltheS.aureusstrainsweresensitivetovancomycin,butshowedvaryingdegreesofresistancetootherantimicrobialagents,soweshouldincreasethemonitoringeffortstoStaphylococcusaureus,inordertodelaythedrugsresistance
5、ofS.aureus.KeyWords:Staphylococcusaureus;MRSA;antibiotics;drugresistance冃录第1章前言11」金黄色葡萄球菌的概述11•1•1黄甸球菌的概志11•1•2金黄色葡萄球菌的危害11.2金黄色葡萄球菌的耐药机制21.2.1金黄色葡萄球菌的耐药性21.2.2金黄色葡萄球菌的耐药机理31.2.3金黄色葡萄球菌的耐药特点61.2.4金黄色葡萄球菌的检测方法61.3MRSA的流行现状81.4本课题的研九目的和乂14第2章实验材料与方法152.1实验材料152.1.1菌株来源152.1.2质控菌株152.1
6、.3仪器152」.4试齐!J152.2实验方法162.2.1标木采集方法162.2.2鉴定程序172.2.3实验方法182.2.4药敏试验19第3章结果与分析213」金黄色葡萄球菌的分布213.2各年度MRSA所占比例223.3MRSA在各类培养阳性标本中的检出率22冃录3.3MRSA在临床部分科室的分布253.5药敏试验结果26第4章总结与展望304.1结论304.1.1金黄色葡萄球菌的临床分布结论304.1.2MRSA的检出率结论304.1.3金黄色葡萄球菌对抗菌药物的敏感性试验结论304.2展望314.2.1MRSA感染的控制措施314.2.2药物研发展
7、望32致谢34参考文献35缩略语表缩略语表缩略词英文名中文名S.aureusStaphylococcusaureus金黄色葡萄球菌MSSAMethicillinSensitiveStaphylococcusaureus甲氧西林敏感金黄色葡萄球菌MRSAmethicillinresistantStaphylococcusaureus耐甲氧西林金黄色衙萄球菌VSSAVancomycin-ScnsitivcStaphylococcusaureus万古霉素敏感的金黄色葡萄球菌VRSAVancomycinresistantStaphylococcusaureus耐万古霉
8、素金黄色葡萄球菌VISAvancomy
