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1、卩孝喘患者血清巨噬细胞炎症蛋白一1a的表达及其临床意义［摘要］目的观察哮喘患者巨噬细胞炎症蛋白Ta(MTP-la)在血清中的表达，探讨其与哮喘严重度的关系。方法选取诸暨市中心医院2012年3〜10月确诊为哮喘的患者80例，根据病程不同分为A组哮喘发作期患者(40例)，B组哮喘缓解期患者(40例)，另选取同期C组40例健康者作为对照。测毘各组研究对象MIP-1Q浓度、外周血嗜酸性粒细胞计数(EOS)和第1秒用力呼气容积(FEV1)占预计值百分比。结果①A组血清MIP-la表达水平为(51.2±6・4)ng/L,明显高于B组的(23.5±3.7)
2、ng/L(t二23.698,P二0.000)及C组(15.1±2.8)ng/L(t二32.683,P二0.000)；与C组比较，B组MIP-1a水平明显升高(t=11.450,P二0.000)o②在外周血EOS计数的比较屮，A组为(0.51±0.34)X109/L,B组为(0.26±0.19)X109/L,均显著高于C组的(0.13±0.08)X109/L(tac=11.658,Pac=0.000；tbc=3.988,Pbc=0.000)；与B组比较,A组明显升高(t二4.059,P二0.000)o③FEV1占预计值百分比的比较中，A组为(5
3、3.7±17.6)%,B组为(68・2±16・3)%均显著低于C组［(88.4±12.5)%］(tac二10.166,Pac二0.000；tbc二6.220,Pbc=0.000)；与B组比较，A组明显降低(t=3.823,P=0.000)。④A组患者血清MIP-la浓度与外周血EOS计数Z间呈正相关(工、=0.422,P0.05)o结论哮喘发作期时血清MIP-la表达水平明显增高，与外周血EOS计数和FEV1占预计值百分比之间存在明显的相关关系，监测血清MIP-1a的水平对哮喘具有一定的诊断价值。［关键词］哮喘；巨噬细胞炎症蛋白-la;嗜酸性
4、粒细胞［中图分类号］R562.25［文献标识码］A［文章编号］1673-7210(2013)11(c)-0066-04Expressionandclinicalsignificaneeofserummacrophageinflammatoryprotein~lalphaofasthmaWANGQianglZHUXinmin21.DepartmentofEmergency,theCentralHospitaiofZhujiCity,ZhejiangProvince,Zhuji311800,China；2.DepartmentofRespirat
5、oryMedicine,People'sHospitalofZhujiCity,ZhejiangProvince,Zhuji311800,China［Abstract］ObjectiveToobservetheexpressionandclinicalsignificanceofserummacrophageinflammatoryproteinTalpha(MIP-1a)ofasthma・Methods80patientswithasthmaintheCentralHospitalofZhujiCityfromMarchtoOctoberi
6、n2012wereselectedanddividedintotwogroupsbydifferentprocessofthedisease・40onsetasthmaticpatientsweredevidedintogroupA,theother40paracmastic且sthmaticpatientsweredevidedintogroupB,another40healthindividualswerecollectedasgroupC(controlgroup).ThelevelsofMIP-1a,thenumberofeosino
7、philicgranulocyte(EOS)andthepercentageofFEV1inpredictionamongthreegroupsweremeasured.Results①ThelevelofMIPTaingroupA[(51.2±6.4)ng/L]washigherthaningroupB[(23.5±3.7)ng/L]andgroupC[(15.1±2.8)ng/L](tab=23.698,Pab=0.000；tac二32.683,Pac二0.000)・The1evelofMTP-1aingroupBwashighertha
8、nthatingroupC(t=11.450,P=0.000)・②ThenumberofEOSingroupA[(0.51+0.34)X109/L]andingro
