《论文_泽菲联合盖诺治疗不耐受顺铂晚期非小细胞肺癌临床观察(定稿)》

《《论文_泽菲联合盖诺治疗不耐受顺铂晚期非小细胞肺癌临床观察(定稿)》》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、泽菲联合盖诺治疗不耐受顺钳晚期非小细胞肺癌临床观察福建医科大学教学医院福州肺科医院肿瘤内科陈群李育宏石琴谢强陈雨燕王成辉王琳摘要目的观察并评价泽菲联合盖诺治疗不能耐受顺釦的晚期非小细胞肺癌的疗效和毒性。方法108例III和IV期非小细胞肺癌既往均未曾放疗或化疗，按ECOG计分W2,生存期超过三个月。WBC计数〉4.0X109/L,肝、肾功能生化指标正常，未有活动性感染征象。36例以泽菲联合盖诺(GN)为一线方案，另外36例以吉西他滨加顺钳(GP),36例以长春瑞滨加顺钳(NP)为一线方案作对照纟(I。结果GP组、NP组和GN纟

2、flRR%分另I」为44.4%、41.7%和36」％,三组疗效比较,宀0.421,P=1.731,(P值>0.05)无统计学差异性。三组的症状缓解率、全身体力状况改善、TTP、一年生存率等亦无显著性差异。GN组与另两组在III〜IV度血液学毒性方面比较无统计学差界(P>0.05)；GN组非血液学毒性比较少，生活质量的影响较少，均有统计学差异性。结论GN方案疗效较好，毒性较低，具有良好耐受的方案，尤其适合于不能耐受顺钠的晚期NSCLC患者。关键词非小细胞肺癌；化学疗法；吉西他滨；长春瑞滨；Gemcitabineplusvinor

3、elbineinthetreatmentofadvancednon-smallcellcancerunendurablecisp1atinum-basedchemotherapyCHENqun，LIyuhong,SIqing,XIEqiang,CHENyuyan,WANGchenhui,WANGlin・DepartmentofTomour，FuzhouPulmonaryHospital,Fuzhou350008，China•[Abstract]ObjectiveToevaluatetheefficacyandtoxicityo

4、fgemcitabineplusvinorelbineinthetreatmentofadvancednon-smallcellcancer(NSCLC)unendurablecisp1atinum-basedchemotherapy.Methods108patientsofthestage3and4NSCLCwithECOGcountsW2point,survivaltimemorethanthreemonths,countsofWBC>4.0X10"/L,functionofliverandkidneyarenormal,

5、noinfectsymptom.allpatientstreatedpreviouslywithoutradiotherapyandchemotherapy,inthose36patientstreatedwithgemcitabineplusvinorelbine(GN)、another36pationtstreatedwithgemcitabinepluscisplatin(GP),and36patienlsvinorelbinepluscisplatin•ResultsTheoverallresponserateswer

6、e44.4%inthegroupGP,41.7%inthegroupNPand36.1%inthegroupGN.NostatisticaldifferenceintheRRbetweenthreemethodsofchemotherapy,(x2=0.421,P=1.731,P>0.05).AlsothatintheTimeToProgress,LifeQuality,SymptomaticRespondandtheYearSurvivalRate•ToxicityofI11~1Vdegreehaematologywerei

7、ndistinguishablybetweenthegroupGNandtheanothertwogroups(P>0.05).Toxicityofnon-haematologyofthegroupGNweremarked(P<0.01=.ConclusionThegroupGNhadthehigherefficacy,thattoxicitywaslower.ItiswelltolerancefortheadvancedNSCLC.ThegroupGNmaybefitforthespecialadvancedNSCLCune

8、ndurablecisplatinum-basedchemotherapy•[keywords]Non-smallcellcancer;Chemotherapy;Gemcitabine;Vinorelbine正文吉西他滨（GEM,G）和长春瑞宾（NVB,N）等第三代抗癌•药物