药学研究进展论文

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1、Theprogressofresearchwithantitumordrug[abstract]:Nearly50yearsofresearchanddevelopmentofanticancerdrugshasmadeconsiderableprogressincancerchemotherapy,particularlyitenablespatientswithhematologicmalignanciessignificantlyprolongsurvivaltime,Butaseriousthreattohumanlifeandhe

2、althaccountedforover90%ofmalignantsolidtumorshasnotyetreachedasatisfactoryeffect.Halfofcancerpatientsarestillnoresponseorresistancetotreatmentandeventuallyleadtotreatmentfailure，sothediscoveryanddevelopmentofnewanticancerdrugsbypharmaceuticalcompaniesisstillverydifficultto

3、befacedwiththechallengeoflong-termmission山.Thischapterprovidessomebriefabouthotareasandthelatestdevelopments.[keyword]:Antineoplastic,Traditionalanticancerdrugs,Newanticancerdrugs1.Traditionalanticancerdrugs1>1Classification:Accordingtothechemicalstructureandsourcesofdrugs

4、itincludesalkylatingantineoplasticagents(Cyclophosphamide),Antimetabolite(Fluorouracil),Antibiotics(doxorubicin.etc.),plantalkaloids(vincristine)、hormones.1.2Cytotoxicanticancermechanismofaction:①Interferingnucleicacidbiosynthesis②thedrugthatdirectlyaffectstheDNAstructurea

5、ndfunction③thedrugthatinterfereswiththeprocessoftranscriptionandRNAsynthesis④thedrugthatinterfereswithproteinsynthesisandfunction1.3Feature:Currentlyconsiderableperiodoftimeorintraditionalcytotoxiccancertherapydrugswillcontinuetobethesubjectofmajordrawbackofthesedrugsispoo

6、rsolidtumorefficacy,sideeffects,easytoproducedrugresistance.Inrecentyears,throughthecancerpatientsduringchemotherapyadversereactionsanalysisconcludedthatmostoftheexistingchemotherapydrugsisnotstrongselectivityininhibitingorkillingtumorcellswhilenormalcells,especiallyprolif

7、erativecells(suchasbonemarrow,hairfollicles)alsoinhibitcytotoxicity.Thus,inthenormaltherapeuticdosechemotherapydrugswhenyoucanmakethebodyproduceadversereactions2.Newanticancerdrugs[6]MoleculartargetedanticancerdrugsAtthemolecularlevel,consideringthedifferencebetweennormalc

8、ellsandthetumorcells、directedtothetumorcells'sometargets,effectivelykilltumorcellswhilemi