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1、CACANCERJCLIN2012;00:000-000AmericanCancerSociety,AmericanSocietyforColposcopyandCervicalPathology,andAmericanSocietyforClinicalPathologyScreeningGuidelinesforthePreventionandEarlyDetectionofCervicalCancer12345DebbieSaslow,PhD;DianeSolomon,MD;HerschelW.Lawson,MD;MaureenKillackey,MD;Shali
2、niL.Kulasingam,PhD;678910JoannaCain,MD;FranciscoA.R.Garcia,MD,MPH;AnnT.Moriarty,MD;AlanG.Waxman,MD,MPH;DavidC.Wilbur,MD;11121314NicolasWentzensen,MD,PhD,MS;LeviS.Downs,Jr,MD;MarkSpitzer,MD;Anna-BarbaraMoscicki,MD;15161718,19,EduardoL.Franco,DrPH;MarkH.Stoler,MD;MarkSchiffman,MD;PhilipE.C
3、astle,PhD,MPH*;EvanR.Myers,MD,MPH*AnupdatetotheAmericanCancerSociety(ACS)guidelineregardingscreeningfortheearlydetectionofcervicalprecancerouslesionsandcancerispresented.Theguidelinesarebasedonasystematicevidencereview,contributionsfrom6workinggroups,andarecentsymposiumcosponsoredbytheAC
4、S,theAmericanSocietyforColposcopyandCervicalPathology,andtheAmericanSocietyforClinicalPathology,whichwasattendedby25organizations.Thenewscreeningrecommendationsaddressage-appropriatescreeningstrategies,includingtheuseofcytologyandhigh-riskhumanpapillomavirus(HPV)testing,follow-up(eg,them
5、anagementofscreenpositivesandscreeningintervalsforscreennegatives)ofwomenafterscreening,theageatwhichtoexitscreening,futureconsiderationsregardingHPVtestingaloneasaprimaryscreeningapproach,andscreeningstrategiesforVCwomenvaccinatedagainstHPV16andHPV18infections.CACancerJClin2012;00:000-0
6、00.2012AmericanCancerSociety.IntroductionCervicalcancerscreeninghassuccessfullydecreasedcervicalcancerincidenceandmortality.TheAmericanCancerSociety(ACS)guidelinefortheearlydetectionofcervicalcancerwaslastreviewedandupdatedin2002;forthefirsttime,those1recommendationsincorporatedhumanpapil
7、lomavirus(HPV)DNAtesting.Sincethattime,numerousstudieshavebeenpublishedthatsupportchangestorecommendedage-appropriatescreeningaswellasthemanagementofabnormalscreen-2ingresults,assummarizedinTable1.BackgroundHigh-qualityscreeningwithcytology(Papanicolaou[Pap]testing)hasmar
