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1、ArchivesofVirologyArchivesofVirology87,331--337(1986)©bySpringer-Verlag1986AntibodyPrevalencetoHumanEntericCoronavirus-likeParticlesandIndicationsofAntiflenicDifferencesBetweenParticlesfromDifferentAreasBriefReportBy]~.I).SCHNAGL1,TEaESAGRECO1,andF.MOREY21Departmentof5~icrobiology,La
2、TrobeUniversity,Bundoora,Victoria,Australia,PathologyLaboratory,AliceSpringsHospital,AliceSprings,NorthernTerritoryWith1FigureAcceptedMay31,1985SummaryAntibodytohumanentericcoronavirusqikeparticleswasdetectedinAustralianAborigines,butatlowerlevelsornotatallinEuropeans.Therewereindica
3、tionsofantigenicdifferencesbetweenparticlesfromdifferentareas.Supportwasprovidedforconsiderationofsuchparticlesasinfectiousagents.Therehavebeenmanyreportsonthefindinginfaecesofhumanentericcoronaviruses/coronavirus-likeparticles(CVLPs)fromnumerousdifferentcountries(reviewedbyMACNAVGgT
4、ONandDAVIES,8),includingAustrMia(11,12).However,therehavebeenreportsfromonlytwolaboratoriesontheirgrowthinorganorcellculture(3,6),andthisinabilitytobereadilygrownhasseverelyhinderedtheircharacterizationandgeneralacceptanceasinfectiousagents,particularlyinthecaseoftheso-cMledCVLPs.The
5、irassociationwithdiarrhoeainacausalrolehasbeensuggestedbynumerousworkers(3,4,5,6,7,13),buttheirexcretionbymanyapparentlyhealthyindividualsinsomeinstances(t,7,9,11,12)hasleadtosomedoubtabouttheroleofCVLPsinentericdisease,particularlyinadults.Arecentreport(5)has,however,suggestedananti
6、genicsimilaritybetweenwhatwereidentifiedashumanentericcoronavirusstrainsandthehumanrespira-torycoronavirus0C43.22b*332R.D.ScHNAG~,TERESAG~Eco,andF.MoRE¥:Thefindingofserumantibodiestothistypeofagenthasbeenreportedinafewspecificdiseaserelatedinstancesinneonatesandinfants(4,5,13)butnoti
7、nthecaseofadults(1).InthiscommunicationwereportontheexistenceandprevalenceofserumantibodytohumanentericCVLPsinCentralAustraliaandMelbourne,Australia,asaresultofasmallbutmoregeneralsurveythanhaspreviouslybeenconducted.WealsoreportontheindicationofpossibleantigenicdifferencesbetweenCVL
8、Psfromdiffer
