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1、Zbl.Bakt.271,351-355(1989)ShortCommunicationOpportunisticInfectionswithCoronavirus-LikeParticlesinPatientsInfectedwiththeHumanImmunodeficiencyVirus?A.M.EIS-HUBINGER,G.STIFTER,andK.E.SCHNEWEISInstitutrurMedizinischeMikrobiologieundImmunologiederUniversitatBonn(Direktor:Prof.Dr.med.K.P.Schaal)
2、With1Figure·ReceivedFebruary10,1989.AcceptedApril6,1989SummaryFrom35patientsinfectedwithHumanImmunodeficiencyVirus(HIV)andbelongingtovariousriskgroups,60stoolspecimenswereexaminedforthepresenceofCoronavirus-likeparticles(CVLP)usingelectronmicroscopy.CVLPweredetectedin5(8%)stoolsamplesfrom5di
3、fferentpatients(14%).Onlyoneofthepatientshaddiarrhoea.ThefivepatientswithCVLP-positivestoolswereallatadvancedstagesofHIVinfection.Theremarkablediscrepancybetweenourdataandanotherstudy,reportingarateof50%CVLP-positiveHIVpatients,mostofthempersistentlysheddingthevirus,isdiscussed.Zusammenfassu
4、ngVon35mitdemhumanenImmundefizienz-Virus(HIV)infiziertenPatientenausver•schiedenenRisikogruppenworden60StuhlprobenelektronenmikroskopischaufdieAn•wesenheitvonCoronavirus-likeparticles(CVLP)untersucht.In5(8%)Stuhlprobenvon5(14%)verschiedenenPatientenwordenCVLPnachgewiesen.Lediglichbeieinem-Pa
5、tientenbestandeineDiarrhoe.AIlePatientenmitCVLP-Nachweisbefandensichineinemfortge•schrittenenStadiumderHIV-Infektion.DieauffalligeDiskrepanzzwischenunserenDatenundeineranderenStudie,beider50%deruntersuchtenHIV-Patienteniiberwiegendpersi•stentmitCVLPinfiziertwaren,wirddiskutiert.IntroductionT
6、heclinicalrelevanceofCoronavirus-likeparticles(CVLP)inacutegastroenteritisofneonatesandinfantsseemstobeundoubted(8).Incontrast,thesignificanceof352A.M.Eis-Hiibinger,G.Stifter,andK.E.SchneweisCVLPasanaetiologicalagentofdiarrhoealdiseaseinadultsisfarlesscertain.Theviruscanbedetectedatthesamera
7、te,i.e.inEuropeabout5to6%,infaecalextractsfromgrown-uppatientswithacutediarrhoeaasfromhealthyadults.Recently,aprospectivestudyofKerneta!.(6)statedthedetectionofCVLPin50%(8/16)ofadultpatientswithAcquiredImmunodeficiencySyndrome(AIDS)orLymphadenopath
