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1、163experiencedcouplingwithshortburstsofventriculartachycar-differenttype.Itispossible,however,thatanticoronavirusdia.antibodiesaretransientandthusnotdetectableinpatientsInviewofthepoorresponsetoquinidine,procainamide,withestablisheddisease.andlignocai
2、neotherantiarrhythmicmedicationswereconsid-ThecoronavirusstrainsusedcamefromDrD.J.Alexander,Cen-ered.Propranololwasrejectedbecauseofthecongestivefail-tralVeterinaryLaboratory,Weybridge;DrS.R.Hopkins,Southeasture.6monthsearlierthepatienthadparticipated
3、inaclinical-ResearchDrH.S.CenterforPoultryLaboratory,Athens;Kaye,pharmacologystudyofnadolol(’Corgard’,Squibb).P.v.c.fre-DiseaseControl,Atlanta;DrK.J.Srensen,StateVeterinaryInstitutequencyhadbeensignificantlyreduced,andalthoughhewasinforVirusResearch,L
4、indholm;DrD.A.J.Tyrrell,ClinicalResearchcongestiveheart-failureatthetime,hisclinicalstatedidnotCentre,Harrow.deteriorate.BecauseofthispreviousresponsenadololwastriedL.GEORGESCUagainandotherantiarrhythmicmedicationswerediscon-P.DIOSItinued.Thedosewas10
5、mgevery6h.Within15h,afteraI.BUTIUcumulativedoseof30mgnadolol,thepatient’smeanP.v.c.MedicalResearchCentre,L.PLAVOSINfrequencywasreducedfrom325±12to47±12ectopicbeats/h1900Timisoara5,RomaniaG.HERZOG(meants.E.).Trigeminyandventriculartachyca
6、rdiadisap-peared.Aplotofp.v.c.frequency,beginningshortlybeforenadololtherapybeganandcontinuingthroughoutthefirstdayoftreatment,isshownintheaccompanyingfigure.Betablock-WARFARINENANTIOMERS,ANTICOAGULATION,adewasconfirmedbyadropinheart-ratefrom65/min(ra
7、ngeANDEXPERIMENTALTUMOURMETASTASIS52-85)to58(range55-65).SIR,--Coumarinderivativesreducemetastasisinexperi-Thepatientwasdischarged10daysafteradmissiononhismentaltumours.1.2Theroleoftheinducedanticoagulationusualdrugswithoutanyantiarrhythmicmedicationo
8、therthaninthiseffecthasbeenquestionedbyHilgard,3who,withnadolol(85mg)oncedaily.Hehasbeenonthistherapyforothers,4-6hassuggestedadirectcytotoxicactivityoncancerover12monthswithaverysatisfactoryresponse.cellsandinhibitionofcellmotilityandofmitoti
