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1、107CONTROLOFMEASLESENCEPHALITISINTHERATBYCD4+T-CELLSU.G.Liebert,U.G,Brinck~lann,B.Bankamp,V.terMeulen,Institotf/itVirologicundImmunhiologie,Universit~itW~u'zburg,Wdrzburg,Germany.Measlesvirus(MV)isaneurotropicviruscausingacuteencephalitisaswellaspersistentinfectionsinsubac,~tesclernsi
2、ngpanencephalitisormeaslesinclusionbodyencephalitis.Clinicalstudieshaveshownthatboth,humeralandcellularimmunereactionsareessentialforovercomingacutemeasles.ItiswelldocumentedthatneutralisingantibodiesdirectedagainsttheMVhemagglutinLn(H)andfusionOF)gly~oproteinsblocktheadsorptionand/us
3、ionstepsofthe~allifecycleandhencez~trictvLralspreadintissue.Detailedknowledgeabouttheroleofthecellularimmuneresponse(Cl~H)toMVisstilllacking.InourratmodelofNIV-inducedfatalencephalitisweshowbyclinical,histopathologicalandvirologicalstudiesthatthehnmunisationofratswithrecombinantvaccin
4、iavirusesCv'VR)expressingMVnucleocapsid(N),FandHproteinsinducesprotectiveimmunityagainstchallengeinfectionwithneurotropicMV,butphospho(P)andmatrix(M)proteinareineffective.InvivodepletionofCD8+Tcellsdoesnotinfluencethepm;octivveffectofVVRimmunisation.MVneutrsL~singantibodieswereshownto
5、oc~artoolatetoaccount.fortheobservedprotection.Furthermore,byadoptivetransferofCD4+TcellswithspecificityforindividualMVproteinswithin24hoursafterinfection,theoccurenceofencephalitisandthespreadofMVintheCNSwaspreventedinweanlingrats.TheseobservationsindicatethataMV-specificCD4+Tcellres
6、ponseintheabsenceofCD8+TcellsandneutralisingantibodiesissufficienttoovercomeviralCNSdiseaseandcleartheinfection.CHARACTERIZATIONOFTHEINFLAMMATORYRESPONSEINTHECENTRALNERVOUSSYSTEMOFRATSWITHDIFFERENTSUSCEPTABILITYTOCORONAVIRUSMHV4-INDUCEDENCEPHALITISR.D6rries,SSchwenderH.ImrichandH.Harm
7、s.Institutf.Virologicu.Immunbiologivd.Universit~t,D-8700W/irzburg,Fed.Rep.Germany.Theinflammatoryresponseinthecentralnervoussystem(CNS)ofLewisandBrownNorwayratswasevaluatedafterintracerebralinfectionwiththemurinecomuavirusMHV4.Distributionofinfiltratinglymphocytesubsetsandviralantigen
8、swasi
