冠状病毒Coronavirusl论文-1987 Inducibility of Ia antigen on astrocytes by murine coronavirus JHM is rat strain dependent.pdf

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1、PublishedJuly1,1987BriefDefinitiveReportINDUCIBILITYOFlaANTIGENONASTROCYTESBYMURINECORONAVIRUSJHMISRATSTRAINDEPENDENTBYPAULT.MASSA,ROBERTBRINKMANN,ANDVOLKERTERMEULENFromtheInstitutfurVirologieandImmunbiologie,UniversitittWurzburg,D-8700Wurzburg,FederalRepublicofGermanyDownlo

2、adedfromInfectionofLewisratswiththemurinecoronavirusJHMleadstoapersistentinfectioninthecentralnervoussystem(CNS)andadiseaseprocessthatsharessomefeatureswithexperimentalallergicencephalomyelitis(EAE)(1-4).Afteranincubationperiodofweeks,asubacutedemyelinatingencephalomyelitis(

3、SDE)developsthatischaracterizedbyparalysis(2).Histologically,themainlesionconsistsofaprimarydemyelinationassociatedwithperivascularcuffingsandacellularinfiltrationofmacrophagesaswellashelperandcytotoxicTlymphocytesjem.rupress.org(1,2).SDEanimalsrevealacell-mediatedimmune(CMI

4、)responsetomyelinbasicprotein(MBP)asdocumentedinadoptivetransferexperiments(1).Inaddition,geneticexperimentsdemonstratethatBrown-Norway(BN)ratsareresistanttoSDE,similartowhathasbeenobservedinEAE(4).Thesefindingsindicateanimmunopathologicalreactionincoronavirus-inducedSDEinLe

5、wisratsthatislackinginBNrats.onMarch17,2015ACMIresponseisgeneticallycontrolledatatleasttwolevels:(a)theabilityoftheanimaltogenerateanencephalolytogenicTcellresponsetoantigenwithinthebrain(foreignorautoantigen)fromitsgeneticallydeterminedTcellreper-toireand(b)thedegreetowhich

6、theantigenispresentedtotheseTcellsinthecontextofclassIandII(Ia)histocompatibilitymoleculeswithinaparticulartissue.ClassII-restrictedTcellsinitiateanimmuneresponsetoinfectionandbothclassI-andII-restrictedTcellsprovidecytolysisofinfectedcells(5).Sincelamoleculesarenormallylack

7、ingoncellsofthebrain(6),theinductionoflawithinthebrainiscrucialfortheinitiallocalpresentationofviralantigenduringinfection.ItmaythereforebeimportantthatastrocytesofLewisratbraincanbeinducedtoexpressladirectlybyJHMvirus(7,8)aswellasbyotherviruses.IFN-ysubsequentlyreleasedbyan

8、tigen-activatedTcellscanfurtherinducetheantigen-presentingfunctionofastrocy