冠状病毒Coronavirusl论文-2005 Fatal Severe Acute Respiratory Syndrome Is Associated with Multiorgan Involvement by Coronavirus.pdf

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1、BRIEFREPORTFatalSevereAcuteRespiratoryepidemicresultedin251probablecasesand44deaths,makingTorontothemostaffectedcenteroutsideofAsia[4].SyndromeIsAssociatedCoronavirusesareadiversefamilyofenveloped,positive-withMultiorganInvolvementstrandRNAvirusesthatcauseawides

2、pectrumofintestinalandrespiratorydiseases.Foranimalcoronaviruses,datasuggestbyCoronavirusthatchangesinthespikeglycoproteinmaycontributetodif-ferencesintissuetropismandvirulence[5].UnliketheentericGabriellaA.Farcas,1,2,4SusanM.Poutanen,3,5,7TonyMazzulli,2,3,5,75,

3、76,76,76andpneumonicillnessesassociatedwiththeanimalcorona-BarbaraM.Willey,JagdishButany,SylviaL.Asa,PeterFaure,PoolakAkhavan,5,7DonaldE.Low,2,3,5,7andKevinC.Kain1,2,3,4,7viruses,illnessesassociatedwithpreviouslyrecognizedhuman1McLaughlin-RotmanCenterforGlobalHe

4、alth,McLaughlinCenterforMolecularcoronaviruses(HCoV-229E,HCoV-OC43,andHCoV-NL63)Medicine,2FacultyofMedicine,3DepartmentofLaboratoryMedicinehadbeenlargelyconfinedtotheupperrespiratorytract[6].andPathobiology,and4InstituteofMedicalScience,UniversityofToronto,56Howe

5、ver,SARS-CoVappearstohavearisenasaresultoftheDepartmentofMicrobiology,MountSinaiHospital,DepartmentofPathology,UniversityHealthNetwork,and7TorontoMedicalLaboratories,Toronto,Canadazoonotictransmissionofananimalcoronavirustohumans,andlittleisknownaboutitspotentia

6、ltissuetropisminhumans[6].AlthoughSARSisprimarilycharacterizedbythepresenceofSevereacuterespiratorysyndrome(SARS)ischaracterizedlowerrespiratorytractinfectionandsubsequentpulmonarybypulmonarycompromise;however,patientsoftenhaveev-compromise,patientsoftenhaveevid

7、enceofotherorgandys-idenceofotherorgandysfunctionthatmayreflectextra-function,includinggastrointestinalsymptomsandabnormalpulmonarydisseminationofSARScoronavirus(SARS-CoV).liverfunction[2,7],aswellassplenicatrophyandlymphade-Wereportonthedistributionandviralloado

8、fSARS-CoVnopathy[8].ThismayreflectwidespreadimmunopathologyorinmultipleorgansamplesfrompatientswhodiedofSARSthepresenceofextrapulmonarySARS-CoVdisseminationandduringth