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《含吡唑基的苯骈咪唑的合成与光谱性能.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、第23卷第5期化学研究中国科技核心期刊2012年9月CHEMICALRESEARCHhxyj@henu.edu.cnSynthesisandspectroscopicpropertiesofabenzimidazolescontainingpyrazolegroupRENTie—gang,LIULei。,WANGJie,LIGui—hui。(1.CollegeofChemistryandChemicalEngineering,HenanUniversity,Kaifeng475004,Henan,China:2.InsituteofPharmaceutics,HenanU
2、niversity,Kaifeng475004,Henan,China;3.KeyLaboratoryofMinistryofEducationforSpecialFunctionalMaterials,HenanUniversity,Kaifeng475004,Henan,China)Abstract:Anovelbenzimidazolecompoundcontainingpyrazolegroupwassynthesizedviaone-stepreactionof0一phenylenediamineand1-pheny1pyrazole一4一carbaldehyd
3、einethanolundermildconditions.Thecompositionandstructureofresultantbenzimidazolecompoundwasanalyzedbymeansofelementalanalysis,MS,HNMR.Theultraviolet—visiblelightspectraandfluo—rescentspectraoftheproductweremeasured.Keywords:benzimidazole;pyrazole;synthesis;spectroscopicpropertyCLCnunlber:
4、O657.33Documentcode:AArticleID:1008—1011(2012)05—0005一O3含吡唑基的苯骈咪唑的合成与光谱性能任铁钢,刘蕾,王杰,黎桂辉。(1.河南大学化学化工学院,河南开封475004;2.河南大学药物研究所,河南开封475004;3.河南大学特种功能材料教育部重点实验室,河南开封475004)摘要:在乙醇溶剂中,于温和条件下以邻苯二胺和1苯基吡唑一4一醛为原料合成了一种结构新颖的含吡唑取代基的苯骈咪唑杂环化合物,通过元素分析,MS,HNMR对所合成的苯骈咪唑化合物的组成与结构进行了表征,同时对该化合物的紫外一可见光谱和荧光光谱进行了
5、研究.关键词:苯骈咪唑;吡唑;合成;光谱性能Nitrogen—containingheterocycliccompoundslikebenzimidazoleandpyrazolehavebeenattractingex—tensiveattentioninpharmaceuticsE]andorganicsynthesis[.Thederivativesofbenzimidazoleandpyrazolehavefoundapplicationsindiversephysiologicalandpharmacologicalareassuchasanti—virals,
6、an—ti-cancers。anti—fungals,anti—inflammatories,anti—oxidation,andtreatmentofhypoglycemiaandphysio—logicaldisordersE3-53.Inthemeantime,benzimidazoleandpyrazolepossessexcellentphotoelectricproper—tiesandarewide1vusedinphotoelectricfunctionalmaterials[]anddisplaydevicelikeorganiclight—emitti
7、ngdiode(OLED)[.Usuallv,twotraditionalmethodscanbeusedtosynthesizebenzimidazolesandtheirderivatives.Oneisthecouplingofphenylenediamineswithcarboxylicacidsortheirderivatives,whichoftenneedsharshdehydratingcondition.Theotherisatwo—stepprocedureinvolvingtheoxidativecycl
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