THE ROLE OF T CELLS IN THE IMMUNOPATHOGENESIS OFRHEUMATOID ARTHRITIS T细胞在免疫发病机制中地作用 类风湿性关节炎.pdf

《THE ROLE OF T CELLS IN THE IMMUNOPATHOGENESIS OFRHEUMATOID ARTHRITIS T细胞在免疫发病机制中地作用 类风湿性关节炎.pdf》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、ARTHRITIS&RHEUMATISMVol.40,No.4,April1997,pp598-60959801997,AmericanCollegeofRheumatologyREVIEWTHEROLEOFTCELLSINTHEIMMUNOPATHOGENESISOFRHEUMATOIDARTHRITISNewPerspectivesDAVIDA.FOXIntroductiondirectedtherapeuticapproacheswouldperhapshavebeenacceptedasawell-demonstra

2、tedfact10yearsago,ConsiderationofthepossibilitythatTlympho-buthasbeenincreasinglydoubtedduetomorerecentcytesmightbecentraltothepathogenesisofrheumatoiddata.WhethertheTcellrepertoireinRAdisplaysaarthritis(RA)firstbecameprominentinthe1980s(1).reproduciblepatternofoli

3、goclonalityandwhethersyno-Onlyafternewapproachesbecameavailableforunder-vialTcellresponsestoidentifiableantigensareimpor-standingthephysiologyoftheTlymphocyte,particularlythegenerationofmonoclonalantibodiesthatidentifiedtantinRAremainpointsofconfusionandcontroversy

4、.thefunctionofimportantTcellsurfacestructures,wasOntheseissuestheavailabledatamayaseasilyprovidetherethedevelopmentofahypothesisfortheetiologyevidenceagainstaroleforTcellsastheydoinfavorofandpathogenesisofRAthatplacedtheTcellatthesucharole.centerofthisdisease.Bythe

5、endofthe1980saTable2summarizeskeyaspectsofthecurrentsubstantialbodyofevidencehadaccumulatedthatjus-evidenceagainsttheimportanceofTcellsinRA.Itisoftifiedconstructionofa“Tcellparadigm”forRA,andcoursedifficulttoprovethataspecificautoantigenthismodelhasformedthebasisfo

6、rtrialsofbiologiccausesahumanautoimmunedisease,butinRA(unliketherapiesandothernovelimmunotherapiesinthetreat-certainotherhumanautoimmuneconditionssuchasmentofthisdisease.myastheniagravis,autoimmunethyroiddisease,andObservationsusedtosupporttheconceptofamultiplescle

7、rosis),strongevidencefortheimportancecentralroleofTcellsinRAarelistedinTable1.Someofanyspecificautoantigenisnotyetavailable.Intheareundisputedfacts,whichanycomprehensiveexplana-absenceofanautoantigen,attemptstoidentifyoligo-tionforthepathogenesisofthediseasemusttak

8、eintoclonalityandspecificityinRATcellpopulationshaveaccount.TheseincludetheabundanceofTlymphocytesnotyieldedclearanswersthatilluminatediseasepath