四种复方聚六亚甲基双胍消毒剂对白色念珠菌杀灭效果比较.pdf

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1、·386·ChineseJournalofDisinfection2008;25(4)文章编号:1001-7658(2008)04-0386-02【研究报告】四种复方聚六亚甲基双胍消毒剂对白色念珠菌杀灭效果比较1崔玉杰张春长陈素良韩艳淑孙克勤(河北省疾病预防控制中心,石家庄050021;1河北省荣军医院)提要目的比较几种以盐酸聚六亚甲基双胍为主要成分的消毒剂杀灭白色念珠菌的效果。方法采用悬液定量杀菌试验方法进行了实验室观察。结果以含500mg/L聚六亚甲基双胍与双癸基二甲基氯化铵组成复方消毒剂和聚六亚甲基双胍与醋酸

2、氯己定组成的复方消毒剂对悬液内白色念珠菌作用1min,平均杀灭对数值均>4.00。用聚六亚甲基双胍与乙醇组成的复方消毒剂对白色念珠菌作用3min,或用聚六亚甲基双胍与苯扎溴铵组成的复方消毒剂作用5min,平均杀灭对数值均>4.00。用含量1000mg/L单方聚六亚甲基胍对白色念珠菌作用7min,平均杀灭对数值为2.45。结论4种复方聚六亚甲基胍消毒剂对白色念珠菌的杀灭效果均较单方聚六亚甲基双胍明显提高,聚六亚甲基双胍与双癸基二甲基氯化铵或与醋酸氯己定组成复方消毒剂杀菌效果更好。关键词聚六亚甲基双胍;复方消毒剂;白色

3、念珠菌;杀菌效果中图分类号:R187.2文献标识码:BCOMPARISIONOFEFFICACYOFFOURKINDSOFPOLYHEXAMETHYLENEBIGUANIDINECOMPOUNDDISINFECTANTSOLUTIONSINKILLINGCandidaalbicans1CUIYu-jie,ZHANGChun-chang,CHENSu-liang,HANYan-shu,SUNKe-qin(HebeiProvincialCenterforDiseasePreventionandControl,Shiji

4、azhuang050021;1HebeiProvincialVeteranHospital,China)AbstractObjectiveTocomparetheefficacyoffourkindsofpolyhexamethylenebiguanidinecompounddisinfectionso-lutionsinkillingCandidaalbicans.MethodSuspensionquantitativegermicidaltestwasusedtocarryoutlaboratoryob-ser

5、vation.ResultsThepolyhexamethylenebiguanidine-didecyldimethylammoniumchloridecompounddisinfectantsolu-tioncontaining500mg/Lpolyhexamethylenebiguanidineandthepolyhexamethylenebiguanidine-chlorhexidinecompounddisinfectantsolutionwitha1mincontacttime,thepolyhexam

6、ethylenebiguanidine-ethanolcompounddisinfectiantsolutionwitha3mincontacttime,orthepolyhexamethylenebiguanidine-bromogeraminecompounddisinfectantsolutionwitha5mincontacttime,killedC.albicanstoreducetheorganismbyalogarithmvalue>4.00.TheaveragekillinglogvalueofC.

7、albicansinsuspensionexposedtothesimplepolyhexamethylenebiguanidinedisinfectaantsolutioncontainingpolyhexam-ethylenebiguanidine1000mg/Lfor7minwas2.45.ConclusionsThefourkindsofcompounddisinfectantsolutionshavebetterefficacythanpolyhexamethylenebiguanidinealonein

8、killingC.albicans.Thepolyhexamethylenebiguanidine-didecyldimethylammoniumchloridecompounddisinfectantsolutionandthepolyhexamethylenebiguanidine-chlorhexidinecompounddisinfectanthav