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1、中国卫生检验杂志2007年8月第17卷第8期ChineseJournalofHealthLaboratoryTechnology,Aug2007;Vol17No81499【卫生与消毒】聚六亚甲基双胍复方消毒剂杀菌性能试验观察12111崔玉杰,张春长,陈素良,韩艳淑,孙克勤(1.河北省疾病预防控制中心,石家庄051021;2.河北省荣军医院,河北保定071000)[摘要]目的:聚六亚甲基双胍复方消毒剂是以盐酸聚六亚甲基双胍为主要成分的消毒剂,为了解其杀菌效果进行了试验观察。方法:采用悬液定量杀菌试验、模拟现场消毒试验、现场消毒试验和金属腐蚀性试验对其杀灭微生物
2、效果和对金属的腐蚀性进行了测试。结果:在悬液定量杀菌试验中,聚六亚甲基双胍复方消毒剂含500mg/L盐酸聚六亚甲基双胍的稀释液,作用1.0min,对金黄色葡萄球菌、铜绿假单胞菌、大肠杆菌杀灭对数值均达5.00以上;对白色念珠菌的杀灭对数值大于4.00。该药含杀菌作用随消毒剂浓度增加、作用时间的延长而增强。以棉签蘸原药液擦拭消毒作用23min,对受试者手和皮肤上自然菌的平均杀灭对数值分别为1.40、1.18,残留菌数均≤5cfu/cm。以其原液擦拭消毒木质表面,作用30min,可使表面自然菌的平均对数值下降1.99;用其原液浸泡黄瓜,作用30min,可使表面污
3、染的大肠杆菌对数值下降3.35。结论:该药对细菌繁殖体和酵母菌有良好的杀灭作用,对不锈钢、铝、铜、碳钢均无腐蚀。可用于手、皮肤、金属物体表面及瓜果蔬菜的消毒。[关键词]盐酸聚六亚甲基双胍;杀灭对数值;杀菌作用[中图分类号]R187.2[文献标识码]B[文章编号]1004-8685(2007)08-1499-03Experimentalobservationongermicidalefficacyofpolyhexamthylene-derivativescom-pounddisinfectionsoluation12111CuiYu-jie,ZhangChu
4、n-chang,ChenSu-liang,HanYan-shu,SunKe-qin(1.HebeiCenterforDiseaseControlandPrevention,Shijiazhuang051021,China;2.HeibeiRongjunHospital,Baoding071000,China)[Abstract]Objective:TheingredientofPolyhexamthylene-derivativescompounddisinfectionsolutionispolyhexamthyleneguanidinehydrochlo
5、ride.Inordertoknowitsgermicidalefficacyandcorrosiveness.Methods:Germicidaltestandmetalcorrosiontestwascarriedout.Results:TheaveragekillinglogvalueofStaphylococcusaureus,PseudomonasaeruginosaandEsherichiacoliexposedtothesolutioncontaining500mg/Lpolyhexamthylene-derivativesfor1minwas
6、>5.00,thatofCandidaalbicanswas>4.00,thatofWipingthenaturalbacteriaonhandsandskinwith625mg/Lpolyhexamthylene-derivativesfor3minwas1.40,1.18.Thatofwoodentablesurfacefor30minwas1.99.Disinfectionofcucumbercontaminatedbyartificialbacteriawiththesolu-tioncontaining625mg/Lpolyhexamthylene
7、-derivativesfor30minwas3.35.Thisdisinfectionsolutionhasnocorrosivenesstomental.ItsmouseoralLD50was>5000mg/kg·bwandtheaverageskinirritationscorewas0.ItsmouseaccumulationcoefficientKwas>5.Conclusion:Thiscompounddisinfecthasgoodefficacyinkillingvegetativeformsofbacteriaandyeasts,nocor
8、rosive-nessandweakcumulati
