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时间:2017-12-07
《补肺活血胶囊对慢性阻塞性肺疾病患者肺功能的影响》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、‘916·中华老年多器官疾病杂志2013年l2月28日第l2卷第12期ChinJMultOrganDisElderly,Vo1.12,No.12,Dec28,2013·临床研究·补肺活血胶囊对慢性阻塞性肺疾病患者肺功能的影响张琳,袁侨英,赵坤2,肖丹2,司良毅2(第三军医大学西南医院:门诊部,老年科,重庆400038)【摘要】目的探讨补肺活血胶囊对慢性阻塞性肺疾病(COPD)患者肺功能的影响,并探索其可能的机制。方法回顾性地分析2010年3月至2012年3月在第三军医大学西南医院住院接受治疗的170例COPD患者的临床资料。其中,常规治疗组(n=50)患
2、者给予常规的COPD治疗,联合治疗组(n:120)在常规治疗的基础上给予补肺活血胶囊口服。检测两组患者的肺功能指标,包括第1秒用力呼气容积和第1秒呼气量占用力肺活量的百分比(FEV和FEV/FVC),统计急性发作次数,采用酶联免疫法(ELISA法)分别测定C.反应蛋白(CRP)、纤维蛋白原(Fib)和D.二聚体(D—D)的含量。结果与常规治疗组比较,联合治疗组患者的肺功能得到不同程度的改善,尤其是FEV/FVC较常规治疗组明显升高,急性发作次数明显减少,CRP,Fib和D.D均有不同程度的降低,差异均有统计学意义(P3、OPD患者的肺功能,其机制可能与改善患者的炎症反应及肺部微血流状态等有关。【关键词】肺疾病,慢性阻塞性;肺功能;纤维蛋白原;C一反应蛋白【中图分类号】R563.9【文献标识码】A【DOI】10.3724/SP.J.1264.2013.00231EficiencyofBufeihuoxuecapsuleonpulmonaryfunctioninelderlywithchronicobstructivepulmonarydiseaseZHANGLin,YUANQiao—Ying,ZHAOKun,XIAODan,SILiangYi(~Outpatientdep4、artment,DepartmentofGeriatrics,SouthwestHospital,theThirdMilitaryMedicalUniversity,Chongqing400038,China)【Abstract】ObjectiveToinvestigatetheeffectofBufeihuoxue(BH)capsule,aChineseTraditionalMedicine,onpulmonaryfunctioninpatientswithchronicobstructivepulmonarydisease(COPD),andtoex5、ploreitspossiblemechanism.MethodsAtotalof170COPDpatientsadmittedinourhospitalfromMarch2010toMarch2012weresubjectedinthisstudy.Theywererandomlydividedinto2groups,onegroupofpatientsweregivenregularCOPDtreatment(routinetreatmentgroup,n=50),andtheothersweregivenBHcapsulecombinedwithc6、onventionaltherapy(combinedtreatmentgroup,n=120).Thepulmonaryfunction,includingforcedexpiratoryvolumeinonesecond(FEVt)andforcedvitalcapacityrateofonesecond(FEV1/FVC)wastestedin2groupsofpatients.AcuteoutbreakofCOPDwasrecorded.SerumlevelsofC—reactiveprotein(CRP),fibrinogen(Fib)andD7、—dimer(D—D)weredeterminedbyenzyme—linkedimmunosorbentassay(ELISA)beforeandaftertreatment.ResultsComparedwithroutinetreatmentgroup,combinedtreatmentgrouphadsignificantlyimprovedlungfunction,especiallyshownaselevatedFEVdFVC,anddecreasedtimesofacuteoutbreak,andreducedselqlmcontentso8、fCRP,FibandD—DfP<0.05).ConclusionBHcapsu
3、OPD患者的肺功能,其机制可能与改善患者的炎症反应及肺部微血流状态等有关。【关键词】肺疾病,慢性阻塞性;肺功能;纤维蛋白原;C一反应蛋白【中图分类号】R563.9【文献标识码】A【DOI】10.3724/SP.J.1264.2013.00231EficiencyofBufeihuoxuecapsuleonpulmonaryfunctioninelderlywithchronicobstructivepulmonarydiseaseZHANGLin,YUANQiao—Ying,ZHAOKun,XIAODan,SILiangYi(~Outpatientdep
4、artment,DepartmentofGeriatrics,SouthwestHospital,theThirdMilitaryMedicalUniversity,Chongqing400038,China)【Abstract】ObjectiveToinvestigatetheeffectofBufeihuoxue(BH)capsule,aChineseTraditionalMedicine,onpulmonaryfunctioninpatientswithchronicobstructivepulmonarydisease(COPD),andtoex
5、ploreitspossiblemechanism.MethodsAtotalof170COPDpatientsadmittedinourhospitalfromMarch2010toMarch2012weresubjectedinthisstudy.Theywererandomlydividedinto2groups,onegroupofpatientsweregivenregularCOPDtreatment(routinetreatmentgroup,n=50),andtheothersweregivenBHcapsulecombinedwithc
6、onventionaltherapy(combinedtreatmentgroup,n=120).Thepulmonaryfunction,includingforcedexpiratoryvolumeinonesecond(FEVt)andforcedvitalcapacityrateofonesecond(FEV1/FVC)wastestedin2groupsofpatients.AcuteoutbreakofCOPDwasrecorded.SerumlevelsofC—reactiveprotein(CRP),fibrinogen(Fib)andD
7、—dimer(D—D)weredeterminedbyenzyme—linkedimmunosorbentassay(ELISA)beforeandaftertreatment.ResultsComparedwithroutinetreatmentgroup,combinedtreatmentgrouphadsignificantlyimprovedlungfunction,especiallyshownaselevatedFEVdFVC,anddecreasedtimesofacuteoutbreak,andreducedselqlmcontentso
8、fCRP,FibandD—DfP<0.05).ConclusionBHcapsu
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