伴发认知障碍帕金森病的弥散张量成像研究

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1、1生!Q箍!鲞箍2Q翅ChinJClinicians(ElectronicEdition)，October15．2013．Vo1．7．No．2·临床论著·伴发认知障碍帕金森病的弥散张量成像研究张雷范国光武成华【摘要】目的探讨弥散张量成像(DTI)对伴发认知障碍帕金森病的诊断价值。方法对11例帕金森病伴痴呆患者，13例帕金森病伴轻度认知障碍患者，12例单纯帕金森病患者及10例正常对照组志愿者行DTI扫描，采用人工勾画感兴趣区(R0I)的方法在DTI参数图上测量各ROI(双侧扣带束、上纵束、下纵束、钩束、齿状核)的各向异性分数(FA)值，采用单因素方差分析方法进行统计

2、分析。结果所有帕金森病组双侧扣带束、双侧上纵束、左侧钩束及右侧齿状核的FA值均低于对照组(尸<0．05)；右侧钩束、左侧齿状核FA值改变仅在单纯帕金森病组、对照组间无统计学差异；左侧下纵束FA值仅在帕金森病伴痴呆组、对照组间有统计学差异(P<0．05)，而右侧下纵束FA值改变均无统计学差异。在各帕金森病组间比较时双侧扣带束、右侧上纵束、双侧钩束、右侧齿状核FA值改变均具有统计学差异，而左侧上纵束FA值改变仅在单纯帕金森病组、帕金森病伴痴呆组间具有统计学差异(P

3、改变可能累及脑白质纤维和小脑。【关键词】帕金森病；认知障碍；磁共振成像，弥散DifusiontensorimagingstudiesofParkinson’sdiseasewithcognitiveimpairmentZ4ⅣGLei,FANGuo-guang,Cheng-hua．DepartmentofRadiology,theFirstHospitalofChinaMedicalUniversity,Shengyang110001，ChinaCorrespondingauthor：FANGuo-guang,EmaiL"fanguog@vip．sina．eom[A

4、bstract]ObjectiveTostudythevalueofdiffusiontensorimaging(DT1)inthediagnosisofParkinson'sdiseasewithcognitiveimpairment．MethodsDT1wasperformedin11patients、出PDD．13PDpatientswithMCI,12purePDpatientsand10controlsubjects．Regionsofinterest(ROI)weredrawninbilateralcingulum，upperlongitudinal，

5、underlongitudinal，uncinatefasciculusandthedentatenucleusonfractionalanisotropy(FA)map．DiferencesinFAbetweenthethesegroupswerestudiedbyone—factorANOVA．ResultsFAvaluesofbilateralcingulum,bilateralupperlongitudinal，leftuncinatefasciculusandfightdentatenucleusinallPDgroupswerelowerthancon

6、trolgroup<0．05)；FAvaluesofrightuncinatefasciculusandleftdentatenucleushadnosignificantchangesonlyinpurePDgroupandcontrolgroup；FAvaluesofleftunderlongitudinalhadsignificantchangesonlyinPDDandcontrolgroup；FAvaluesoffightunderlongitudinalinallgroupshadnosignificantchanges．FAvaluesofbilat

7、eralcingnlum，fightupperlongitudinal，bilateraluncinatefasciculusandrightdentatenucleushadsignificantchangesinallPDgroupswhentheywerecomparedbetweeneachother；FAvaluesofleftupperlongitudinalhadsignificantchangesonlyinpurePDandPDDgroup；FAvaluesofleftdentatenucleushadnosignificantchangeson

8、lyinp