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1、Thl7细胞相关细胞因子在类风湿性关节炎发病中的临床意义陆扬光1余志辉1王晓娟2通迅作者(1佛山市第五人民医院检验科528211;2佛山科学技术学院医学院广东佛山528211)【摘要】目的探讨Thl7细胞相关细胞因子IL-17.IL-6>IL・23在类风湿关节炎(rheumatoidarthritis,RA)发病机制中的作用。方法用酶联免疫吸附法检测35例活动组RA患者、35例缓解组RA患者及30例健康人血清IL・17、IL・6、IL・23的水平，并分析它们与活动度和实验室指标的关系。结果RA活动组和缓解组血清IL・23、IL・6水平均明显
2、高于对照组(p<0.05),而RA活动组与缓解租相比，差异亦有统计学意义(p<0.05)oRA活动组与缓解组血清IL・17水平均高于对照组(p<0.05),但RA缓解纟且与对照组比较差异无统计学意义(p>；0.05)oRA患者血清IL-17>IL-6和IL-23水平分别与DAS28评分、CRP、ESR,DAS28评分、RF、CRP、ESR和DAS28评分、ESR相关(p<0.05)oRA患者血清IL-17>IL-6和IL-23水平之间互为正相关关系。结论Thl7细胞相关细胞因子IL-17>IL・6、IL・23均在RA的
3、发生、发展过程中起着重要作用，并可作为RA活动参考指标。【关键词】类风湿关节炎Thl7细胞IL-17IL-6IL-23【中图分类号】R593.22【文献标识码】A【文章编号】2095-1752(2014)20-0048-02ClinicalSignifcanceofThl7CellsRelatedCytokinesonRheumatoidArthritisLUYang-guang.YUZhi-hui,WangXiao-juanDepartmentofClinicalLaboratory,TheFifthHospitalofFoshan,Gu
4、angdongFoshan528211,China【Abstract]ObjectiveToinvestigateclinicalsignificancesofThl7relatedcytokinesIL-17,IL-6andIL-23inpatientswithRA.MethodsThepatientsweredividedintodifferentgroupsaccordingtotheRAdiseaseactivityscore(DAS28),35patientswithactiveRAand35patientswithinactiv
5、eRA.Thirtyhealthyvolunteerswererecruitedasthenormalcontrol.ConcentrationsofserumIL-17,IL-6andIL-23weremeasuredbyEnzymelinkedimmunosorbentassay(ELISA).TherelationshipbetweenThl7relatedcytokinesandlaboratorydatawereanalyzedatthesametime.ResultsComparedwiththenormalcontrol,th
6、elevelsofserumIL-23andIL-6inpatientswithRAweresignificantlyincreased(p<0.05),andthereshowedthesatatisticdifferencesbetweenpatientswithactiveRAandinactiveRA(p<O.O5).Comparedwithnormalcontrols,thelevelsofserumIL-17inpatientswithRAweresign讦icantlyincreased,andthereshowe
7、dnostatisticdifferencesbetweenpatientswithinactiveRAandnormalcontrols.ThelevelsofserumIL-17,IL-6andIL-23werepositivelycorrelatedwithDAS28Score>CRP、ESR,DAS28Score>RF>CRP>ESRandDAS28Score、ESRrespectively(p<0.05).ConclusionTheresultssuggestthatThl7relatedcytokinesIL-17,IL-
8、6andIL-23mayplayimportantrolesinthepathogenesisofRAandcanbeindicatorsofdiseaseactivity.[K
