三维适形放疗联合紫杉醇、顺铂同步化疗对局部晚期食管癌的疗效.pdf

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1、2Q生月笠3鲞筮Z期jingSUMedJ，Apri12013，V0l39，No．7●论著●三维适形放疗联合紫杉醇、顺铂同步化疗对局部晚期食管癌的疗效王达飞朱国民陈胜东蒋勤娟【摘要】目的观察三维适形放疗(3DCRT)联合紫杉醇、顺铂同步化疗治疗局部晚期食管癌的近期疗效。方法局部晚期食管癌患者56例随机均分为两组，A组采用3DCRT联合化疗，B组行单纯3DCRT治疗。比较两组的近期疗效、生存率以及不良反应。结果所有患者均获随访1年以上。A组总有效率高于B组(89．3vs．64．3)(．P<0．05)。A组1年生存率高于B组(85．7vs．67．8)(P

2、5)。A组的骨髓抑制和胃肠反应发生率明显高于B组(67．9％vs．17．9和85．7％vs．25．0)(P

3、ininlocallyadvancedesophagealcarcinomaWANGDafei，ZHUGuomin，CHENShengdong，eta1．DepartmentofRadiotherapy，TumourHospitalofYingxing，Yingxing214200，CHINA[Abstract]0bjectiveToevaluatetheclinicalefficacyofcombineduseof3-dimensionalconformalradiotherapy(3DCRT)andconcurrentchemotherapyofpac

4、litaxelandcisplatininlocallyadvancedesophagealcarcinoma．MethodsFifty-sixpatientswithlocallyadvancedesophagealcarcinomaweretreatedwith3DCRTandconcurrentchemotherapyofpaclitaxelandcisplatin(groupA，28cases)or3DCRTalone(groupB，28cases)．Theclinicalefficacywasobservedandcompared．Results

5、Thepatientswerefollowedupformorethanoneyear．ThetotaleffectivenessrateofgroupAwashigherthanthatingroupB(89．3vs．64．3)(P<0．05)．Sodidthe1-yearsurvivalrate(85．7vs．67．8)(P<0．05)．TheincidenceratesofbonemarrowinhibitionandgastrointestinalresponsewerehigheringroupAthanthoseingroupB(67．9vs．

6、17．9and85．7vs．25．O)(P

7、iotherapy；ChemotherapylJiangsuMedJ，Aprif2013，39(7)：827—829．1作者单位：214200江苏省，宜兴市肿瘤医院放疗科[3]FerraraA．HighBodyMassIndexbeforePrenancylinkedtoET]OngKK，DungerDB．Perfinatalgrowthfailure：theroadtoGDM[J]．ObstesGynecol，2003，106(2)：340．obesity，insulinresistanceandcardiovasculardiseaseinadults

8、[4]JainNJ，DenkCE，KruseLK，eta1．Mat