大鼠中风模型的超小氧化铁粒子神经血管成像-论文.pdf

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1、波谱学杂志第31卷第1期V0l_31No．12014年3月ChineseJournalofMagneticResonanceMar．2014Article：1000-4556(2014)01-020—12USPIOHighResolutionNeurovascularImaginginaRatStrokeModelofTransientMiddleCerebralArteryOcclusionSHENYi—rain，ZHENGWei—li，CHENGYu—chungN，DINGYu—chuan，HIGASHIDATetsuhiro，，Jie，YEYong—q

2、uan，RAYNAUDJeall—Sebastien，HAACKEEMark(1．DepartmentofRadiology,WayneStateUniversitySchoolofMedicine，Detroit48201，USA；2．DepartmentofNeurologicalSurgery,WayneStateUniversitySchoolofMedicine，Detroit48201，USA；3．GuerbetResearch，Aulnay-Sous-Bois93600，France；4．DepartmentofBiomedicalEngine

3、ering，WayneStateUniversity,Detroit48201，USA)Abstract：Angiogenesisinducingagents，suchasSildenafil，canbeusedtotreatstroke．Inthisstudy．USPIO—enhancedMRJwasusedtovisualizecollateralvesselsinthepenumbralareaoflesionsofratssubjectedtotransientmiddlecerebralarteryocclusion(tMCA01．andtheev

4、aluateeficacyoftheSildenafiltreatment．Here，P904，aUSPIOagent，wasusedasaT1reducingagentatalowdoseforMRangiographyandasaT2reducingagentatamoderatedoseforvisualizationofverysmallvesselsongradientechosusceptibility—weightedimaging(SWI)．SWIscanswithout／withUSPIOinjectionwereperformedfort

5、hefollowingcases：tMCA0withoutanytreatment(月=5)，tMCAOwithSildenafiltreatment(=6)，andshamtMCAO(=1)atfourdifferenttimepoints(i．e．，baseline，24h，twoweeksandfourweeksaftertMCAO)．Thepresenceofnewlydevelopedvesselsintheperipheryoftheischemiccorewasonlyobservedinthoseanimalsshowingsevereisc

6、hemicbraindamageandatthesametimereceivedSildenafiltreatmentattwoweeksposttMCAO．Thisworksuggeststhat，at7T，highresolutionSWIinconiunctionwithUSPIOinectionatamoderatedoseCarlbeusedtovisualizepost．strokeangiogenesisiflthetMCA0ratmode1．Keywords：MRI，stroke，angiogenesis，SWI，USPIO，neurovas

7、culatm'eCLCnumber：O482．53Documentcode：AReceiveddate：2013．10-16：Reviseddate：2013-11-12Foundationitem：HeartandStrokeFoundationofCanada(HSFC)，SynchrotronMedicalImagingTeamGrant(CIF99472)Biography：SHENYi—min(1961一)，male，bominJiangsu，PhD．，hisresearchfocusesonMRI，Te1．：+01—313-966—0579，fa

8、x：+01-313—745—9182．E—mail：