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时间:2020-05-07
《成人活体右半供肝移植术后移植肝再生的动态研究-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·198·中华器官移植杂志2014年4月第35卷第4期ChinJOrganTransplant,April2014,V01.35,No.4成人活体右半供肝移植术后移植肝再生的动态研究季倩褚志强沈文郑虹祁吉【摘要】目的利用多层螺旋CT评价成人活体右半供肝移植术后移植肝的再生情况及影响移植肝再生的相关因素。方法63例活体肝移植受者纳入研究,利用多层螺旋CT及IQQA-Liver工作站定期测量移植肝体积,计算并比较术后不同时间段的肝再生率,利用逐步回归分析得出术后不同时间段肝再生率与受者相关因素的回归方程。结果术后0.5个月内,移植肝体积快速增长,肝再生率(LRR)达到最大
2、值(106.11±30.90),随后即开始缓慢下降。术后0.5和1个月时LRR与术后3和6个月问的差异均有统计学意义(P0.05);术后0.5个月时不同术前Child-Pugh分级受者间肝再生率的差异有统计学意义(P<0.05),其余各时间段无明显差异(P>0.05);移植肝体积与受者术后不同时间段肝再生率间呈负相关(P3、多层螺旋CT测量移植肝体积是评价术后肝再生的有效方法。【关键词】肝移植;活体供者;移植物;肝再生DynamicstudyofgraftregenerationafterrightlobeadultlivingdonorlivertransplantationJiQian,ChuZhiqiang,ShenWen,ZhengHong,QiJi.DepartmentofRadiology,nninFirstCentralHospital,n口in300192,China[Abstract]ObjectiveToevaluategraftregenerationandinfl4、uencingfactorsafterrightlobeadultlivingdonor1ivertransplantation(LDLT)usingMSCT.MethodSixty-threelivingrecipientswereincludedinthisstudy.WemeasuredgraftvolumeperiodicallybyusingMSCTandIQQA—LiverWOrkstation.Theliverregenerativeratio(LRR)ofdifferentstagesofrecipientsafterLDLTwascalculated5、andcompared,andstepwiseregressionanalysiswasdonetosetuptheregressionequation.ResultWithin0.5monthafterLDLT,graftvolumewasinereasedrapidly,andLRRreachedmaximumr(106.11±30.90)],thendecreasedslowly.TherewassignificantdifferenceinLRRamong0.5,1monthand3,6monthsafterLDLT(P<0.05).Thefollowingf6、actors,includingwhetherthegraftcontainingmiddlehepaticveinornot,ageandsexofrecipients,hadnosignificantinfluenceonLRRafterIDLT(P>0.05).Thestatusof1iverfunctionofrecipientspreoperativelyhadsignificantinfluenceonLRR0.5monthafterLDLT(P<0.05).ThereW8Ssignificantlynegativecorrelationbetweenth7、egraftvolumeandLRRsofrecipientsatdifferentstagesafterUDr(P<0.05).Regressionequationcouldbederived.ConclusionMostevidentgraftregenerationoccursinearlystageafteradultLDLT.TherearemanyanddifferentfactorsinfluencinggraftregenerationatthedifferentstagesafterLDLT.Graftvolumetricmeasu
3、多层螺旋CT测量移植肝体积是评价术后肝再生的有效方法。【关键词】肝移植;活体供者;移植物;肝再生DynamicstudyofgraftregenerationafterrightlobeadultlivingdonorlivertransplantationJiQian,ChuZhiqiang,ShenWen,ZhengHong,QiJi.DepartmentofRadiology,nninFirstCentralHospital,n口in300192,China[Abstract]ObjectiveToevaluategraftregenerationandinfl
4、uencingfactorsafterrightlobeadultlivingdonor1ivertransplantation(LDLT)usingMSCT.MethodSixty-threelivingrecipientswereincludedinthisstudy.WemeasuredgraftvolumeperiodicallybyusingMSCTandIQQA—LiverWOrkstation.Theliverregenerativeratio(LRR)ofdifferentstagesofrecipientsafterLDLTwascalculated
5、andcompared,andstepwiseregressionanalysiswasdonetosetuptheregressionequation.ResultWithin0.5monthafterLDLT,graftvolumewasinereasedrapidly,andLRRreachedmaximumr(106.11±30.90)],thendecreasedslowly.TherewassignificantdifferenceinLRRamong0.5,1monthand3,6monthsafterLDLT(P<0.05).Thefollowingf
6、actors,includingwhetherthegraftcontainingmiddlehepaticveinornot,ageandsexofrecipients,hadnosignificantinfluenceonLRRafterIDLT(P>0.05).Thestatusof1iverfunctionofrecipientspreoperativelyhadsignificantinfluenceonLRR0.5monthafterLDLT(P<0.05).ThereW8Ssignificantlynegativecorrelationbetweenth
7、egraftvolumeandLRRsofrecipientsatdifferentstagesafterUDr(P<0.05).Regressionequationcouldbederived.ConclusionMostevidentgraftregenerationoccursinearlystageafteradultLDLT.TherearemanyanddifferentfactorsinfluencinggraftregenerationatthedifferentstagesafterLDLT.Graftvolumetricmeasu
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