小剂量米非司酮对子宫内膜异位症患者血清VEGF和HGF的影响-论文.pdf

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1、·6·中国实用医药2014~9月第9卷第25期ChinaPracMed，Sep2014，Vo1．9，No．25小剂量米非司酮对子宫内膜异位症患者血清VEGF和HGF的影响李铁燕【摘要】目的探讨小剂量米非司酮对子宫内膜异位症患者血清血管内皮生长因子(VEGF)和肝细胞生长因子(HGD的影响。方法126例子宫内膜异位症患者随机分为两组，观察组63例，采用米非司酮6．25mg，1次／晚；对照组63例，采用米非司酮l2．5mg，1次，晚，两组共治疗3个月。测定治疗前后血清VEGF和HGF。结果治疗后对照组总有效率为90．5％，观

2、察组总有效率为88．9％；两组总有效率比较，差异无统计学意义(2=1．62，P>0．o5)。两组治疗后患者痛经VAS评分较治疗前均有明显降低0=6．9216，6．0614，P0．05)。治疗后两组患者的血清VEGF和HGF较治疗前均有明显降低O=5．9248，4．9928，P<0．01；t=3．0616，3．1734，PO．05)。对照组治疗期间有13

3、例发生不良反应，发生率为20．6％；观察组有8例发生不良反应，发生率为12．7％；观察组不良反应发生率明显少于对照组(x=5．72，P

4、ogyandObstetrics，FamilyPlanningServiceStationofKuanchengManchuAutonomousCounty,Chengde067600,China【Abstract】ObjectiveToinvestigatetheinfluenceofsmalldosesofmifepristoneonserumvascularendothelialgrowthfactor(VEGF)andhepatocytegrowthfactor(HGF)inpatientswithendomet

5、riosis．MethodsAtotalof126casesofendometriosiswererandomlydividedintotwogroups．Theobservationgroup(n=63cases)wastreatedbymifepristone6．25mgforltime／nisht，andthecontrolgroup(n=63cases)receivedmifepristonel2．5mgforltime／nJght．Thetreatmentlastedfor3months．SerumVEGFan

6、dHGFweredetectedbeforeandaftertreatment．ResultsThetotalefectiverateswere90．5％inthecontrolgroupand88．9％intheobservationgroup．Therewasnosignificantdiferencebetweenthetwogroups(=1．62，P>0．o5)．ThedysmenorrheaVASscoresofpatientsafterthetreatmentwerelowerthanbeforethetr

7、eatment(f=6．9216，6．0614，P<0．01)，andtherewasnostatisticalsignificanceofthedifferencebetweenthetwogroupsafterthetreatmentf仁0．6218，P>0．05)．SerumVEGFandHGFweresignificantlyloweredintwogroupsafterthetreatment，comparingwithbeforethetreatmentO=5．9248，4．9928，P

8、616，3．1734，P0．05)．Inthecontrolgroup，there