骨化三醇治疗血透患者继发性甲状旁腺功能亢进的疗效观察.pdf

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1、临床与实践Linchuangyushan《中外医学研究》第12卷第30期(总第254~j)2014年1o月骨化三醇治疗血透患者继发性甲状旁腺功能亢进的疗效观察马金贵①【摘要】目的：探讨骨化三醇冲击治疗慢性肾功能衰竭血透患者继发性甲状旁腺功能亢进的临床疗效和安全性。方法：选取2013年2月一2014年4月在苏州相城人民医院肾内科就治的慢性肾功能衰竭维持性血液透析患者，共69例，观察经骨化三醇冲击治疗4、8、12、24周后，血钙、血磷和血iFrH水平的变化。结果：与治疗前相比，经骨化三醇治疗后4、8、12、24周，所有患者血iPTH均有下降，且呈持续下降趋势，8、12、24周与治疗前比较，差异有

2、统计学意义

3、ismFollowingLong—termHemodialysis／MAJin-gui．／／ChineseandForeignMedicalResearch，2014，12(3O)：14-16【Abstract】Objective：ToinvestigatetheefficacyandsafetyofCalcitriolinthetreatmentofsecondaryhyperparathyroidism(SHPT)followinglong—termhemodialysis．Method：Atotalof69patientsatendstagerenaldiseasethatrequir

4、edmaintenancehemodialysiswereenrolledintothisclinicaltrialduringtheperiodfromFeb2013toApr2014atSuzhouXiangchengPeople’SHospita1．Serumlevelsofcalcium，phosphorus，andiPTHwereassayedforpatientstreatedwithCalcitriolpriortotreatmentand4weeks，8weeks，12weeks，and24weekstoinvestigatechangesintheseparameters．

5、Result：Whencomparedtopre—treatment，theserumlevelofiPTHforallsubjectswasdecreasedafterCalcitrioltreatmentfor4weeks，8weeks，12weeks，and24weeks，thereweresignificantlydifferencesbetween8weeks，12weeks，24weeksandbeforetreatment(P<0．05)．After24weeks’treatmentofCalcitriol，iPTHlevelin52subjectswasdownregulat

6、edtothetargetedlevelswithaneffectiverateof75．4％．Aftertreatment．serumlevelofcalciuminallsubjectswasobservedincreasedslightlybutwithnosignificantdifference(P>0．05)．Conclusion：ItisconcludedthatCalcitriolisbeneficialandsafetyinthetreatmentofsecondaryhyperparathyroidismfollowinglong-termhemodialysis．【Ke

7、ywords】Chronicrenal~ilure；Caleitriol；Secondaryhyperparathyroidism；Rocahrol·First-author’saddress：SuzhouXiangchengPeople’SHospital，Suzhou215131，China维持性血液透析fmaintenancehemodialysis，MHD)目前依然6例。入选标准：(1)所有患者接受常