浆母细胞淋巴瘤的临床病理特征的研究.pdf

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1、范国庆，等浆母细胞淋巴瘤的临床病理特征的研究浆母细胞淋巴瘤的临床病理特征的研究范国庆，刘一雄，文璐，王映梅，王璐，张月华，王哲，闰庆国，杨兰，郭英TheCIiniC0pafh0l0giCaIfeaturesofplasmablsticlymphomaFanGuoqing，LiuYixiong，WenLu，WangYingmei，WangLu，ZhangYuehua，WangZhe，YanQingguo，YangLan，GuoringDepartmentofPathology，StateKeyLaboratoryofCancerBiology，xiji~gHospital，Four

2、thMilitaryMedicalUniversity，ShaanxiXi'an710032，China；DepartmentofHematology，XijingHospital，FourthMilitaryMedicalUniversity，ShaanxiXi'an710032，China．【Abstract】Objective：Plasmablasticlymphoma(PBL)isararesub—groupofdiffuselargeBcelllymphomaoccur-ingintheclinicalsettingofHIV／AIDSandlatentEpstein—

3、Barrvirus(EBV)infections．Duetotherarityofthisdis—ease，thecommonfeaturesofPBLofChinesepatientsaremuchlessunderstood．Inordertoanalyzetheclinicopatho—logicalcharacterofPBLinourcountrywedesignedthecurrentstudy．Methods：Clinicalanalyzewasmadeon10PBLcases．Immunophenotypewasdetectedbyimmunostaining．E

4、BVinfectionwasdetectedbyEBERhybridizationinsitu．MYCgenetranslocationandduplicationweredetectedbyfluorescencehybridizationinsitu．Results：PBLoccurredmainlyinextranodalorgans．Itshowedanaggressiveclinicalcoursewithshortsurviva1．IthadnodistinctcorelationwithHIVinfectionorimmnodeficiency．TherateofE

5、BVinfectionwas50％．TheimmunophenotypewascharacterizedbylackingBcellmarkersbutpossessingplasmablasticmarkers．Ki一67indexwashigh．TherateofMYCgenetrans—locationwas10％whileMYCgeneduplicationwas10％．Conclusion：PBLmainlyoccuredinimmunocompetentpa—tientsinourcountry．IthadnodistinctcorelationwithHIVinfe

6、ctionorimmunodeficiency．IthadalowerEBVinfec—tionrate．MYCgeneaberationsweredetectedbutthepositivitywaslow(20％)．Them0rphology，immun0phenotypeandaggressiveclinicalcharacterofPBLaresimilartothatinwesterncountries．【Keywords】plasmablasticlymphoma；HIV；Epstein—Barrvirus；MYCgenetranslocation；anaplasti

7、cplasmacytomaModernOncology2014．22(11)：2690—2694【摘要】目的：浆母细胞淋巴瘤是弥漫性大B细胞淋巴瘤的一个罕见亚类。我国对浆母细胞淋巴瘤的报道多为个案报道，缺乏对其共性的研究。为了探求我国浆母细胞淋巴瘤的临床病理特征，我们进行了本次研究。方法：对10例浆母细胞淋巴瘤进行临床资料分析，免疫组化法检测免疫表型，原位杂交法检测EB病毒感染情况，用原位荧光杂交法检测MYC基因的易位和扩增。结果：浆母细胞淋巴瘤多发生于结外器官，发现时即为临床晚