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1、肠道菌群紊乱和自闭症2SeminImmunopathol. 2015Jan;37(1):5-16.doi:10.1007/s00281-014-0456-2.Epub2014Oct22.Towardthecomprehensiveunderstandingofthe gut ecosystemviametabolomics-basedintegratedomicsapproach.AwW1, FukudaS.Authorinformation·1InstituteforAdvancedBiosciences,KeioUniversity,
2、246-2Mizukami,Kakuganji,Tsuruoka,Yamagata,997-0052,Japan.AbstractRecentadvancesinDNAsequencingandmassspectrometrytechnologieshaveallowedustocollectmoredataonmicrobiomeandmetabolometoassesstheinfluenceofthe gut microbiota onhumanhealthatawhole-systemslevel.Majoradvancesinm
3、etagenomicsandmetabolomicstechnologieshaveshownthatthe gut microbiota contributestohostoverallhealthstatustoalargeextent.Assuch,the gut microbiota isoftenlikenedtoameasurableandfunctionalorganconsistingofprokaryoticcells,whichcreatestheunique gut ecosystemtogetherwiththeh
4、osteukaryoticcells.Inthisreview,wediscussindetailtherelationshipbetween gut microbiota anditsmetaboliteslikecholine,bileacids,phenols,andshort-chainfattyacidsinthehosthealthandetiopathogenesisofvariouspathologicalstatessuchasmultiplesclerosis, autism,obesity,diabetes,andc
5、hronickidneydisease.Byintegratingmetagenomicandmetabolomicinformationonasystemsbiology-wideapproach,wewouldbebetterabletounderstandthisinterplaybetween gut microbiomeandhostmetabolism.Integrationofthemicrobiome,metatranscriptome,andmetabolomeinformationwillpavethewaytowar
6、danimprovedholisticunderstandingofthecomplexmammaliansuperorganism.Throughthemodelingofmetabolicinteractionsbetweenlifestyle,diet,and microbiota,integratedomics-basedunderstandingofthe gut ecosystemisthenewavenue,providingexcitingnoveltherapeuticapproachesforoptimalhosthe
7、alth.ProcNutrSoc. 2014Oct14:1-6.[Epubaheadofprint]Nutritionalmanagementof(some) autism:acaseforgluten-andcasein-freediets?WhiteleyP1.Authorinformation·1ESPAResearch,2AHyltonPark,HyltonParkRoad,SunderlandSR53HD,UK.AbstractAutism spectrumdisordersrepresentadiverseandheterog
8、eneousarrayofconditionsunifiedbythevariablepresenceofspecificbehavioursimpactingsocialandcommuni
