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1、高血压病、冠心病与血尿酸及血脂相关性探讨作者：冯美云王丛张昕王增帅张文祥【关键词】冠心病【摘要】目的探讨高血压病、冠心病与血尿酸（UA）及血脂的相关性。方法回顾性分析101例高血压病患者即高血压组（HBP）、101例冠心病患者即冠心病组（CHD）、166例高血压病合并冠心病患者即高冠心组和115例健康正常人（对照组）的UA及血脂检测值进行比较。结果3组UA、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、极低密度脂蛋白胆固醇（VLDL-C）.动脉硬化指数（LDL/HDL）均显著高于对照组（PV0.01）;而高密度脂蛋白
2、胆固醇（HDL-C）显著低于对照组（PV0.01）,高尿酸血症（HUA）在HBP组、CHD组、高冠心组中分别各占17.8%.9.1%.15.9%;相关分析显示，3组UA均与TG、TC、LDL-C.VLDL-C呈正相关，r=0.288、0.194.0.141、0.218,P<0.01;与LDL/HDL亦呈正相关，r=0.194,P<0.05;与HDL-C呈负相关（r=-0.291,P<0.01）o3组间对比分析,HBP组及高冠心组UA显著高于CHD组（PV0.05）,HBP组与高冠心组两组间UA比较，差异无显著性（P>0.05）;高冠心组TG
3、和VLDL-C显著高于CHD组（P<0.05）,高冠心组与HBP组、HBP组与CHD组组间TG和VLDL-C比较差异无显著性（P>0.05）。结论血尿酸升高是高血压病、冠心病的危险因素之一；UA升高与脂质代谢异常有关。【关键词】高血压病；冠心病；血尿酸；血脂Studyonrelationshipbetweenhypertensionandcoronaryheartdisease,levelofserumurinaryacidandblood1ipidFENGMei-yun,WANGCong,ZHANGXin,etal.First-aidCe
4、ntre,TheSecondAffi1iatedHospitalofMedicalInstituteofBaotou,Baotou014030,China[Abstract]ObjectiveToexplorethecorrelationbetweenthelevelofserumurinaryacidandbloodlipidwithhypertension,coronaryheartdisease.MethodsWeretrospectivelyanalyzedthelevelofserumurinaryacidandblood1ipi
5、dwithhypertension（n=101）,coronaryheartdisease（n=l10）,hypertensionincombinantcoronaryheartdisease（n=166）,controlgroup（n=l15）,respectively.ResultsTheconcentrationofUA,TG,TC,LDL-C,VLDL-C,LDL/HDLofa11patientsgroupwashigherthanthoseofcontrolgroup（P<0.01）coronaryheartdisease,hyp
6、ertensionincombinantcoronaryheartdiseasewas17.8%，9.1%,15.9%,Therewereapositivecorrelation（r=0.288,0.194,0.141,0.218,P<0.01）betweenUAandTG,TC,LDL-C,VLDL-C,andLDL/HDL（r=0.194,P<0.05）;andanegativecorrelation（r=~0.291>P<0.01）betweenUAandHDL-C.TheconcentrationofHDL-Cwas1owertha
7、nthatofcontrolgroup,P<0.01,Thepercentageofhyperuricemiainhypertensiono『UAinHBPandhypertensionincombinantcoronaryheartdiseasegroupwashigherthanCHDgroup,P<0.05;thelevelofserumurinaryacidwasnotdifferentinHBPandhypertensionincombinantcoronaryheartdiseasegroup,P>0.05.Theconcent
8、rationofTGandVLDL-CinhypertensionincombinantcoronaryheartdiseasegroupwashigherthanCHDgrou
