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1、CentralJournalofEndocrinology,Diabetes&ObesityReviewArticleSpecialIssueonTheAnticancerEffectofAntidiabeticDrug-MetforminMetformin,theMostCommonlyCorrespondingauthorShumeiMeng,DepartmentofInternalMedicine,OhioStateUniversity,557McCampbellHall,1581DoddUsedAnti-DiabetesDrugDrive,Colu
2、mbus,OH,43210,USA,Tel:6146853333;Fax:6143660345;Email:ShumeiMengSubmitted:15March2014DepartmentofInternalMedicine,OhioStateUniversity,USAAccepted:28May2014Published:29May2014AbstractISSN:2333-6692Metforminasthefirstlinetherapyfortype2diabetesmellitushasitsuniqueCopyrightattraction
3、foritsweightlossandpossiblemacrovascularbenefit.Inaddition,recent©2014MengaccumulatingepidemiologicalandclinicalevidencesuggestsmetforminmaybeaOPENACCESSpotentialanticancermedicationasanadjuvanttherapyorachemopreventiongiventheincreasedprevalenceofobesityanddiabetesmellitusincance
4、rpatientsandthelowcostandsafetyofthedrug.MetforminmayworkthroughmultiplepathwaystoKeywordsinhibitcancercellgrowthandproliferation.Epidemiologicalandclinicaldatawere•Metforminsummarizedinthisreview.Morecarefullydesignedlongerandlargerrandomized•Hypoglycemiccontrolledtrialsinselecte
5、dcancerpopulationinthefutureareneeded.•AnticancerABBREVIATIONcancercellsevenwhenoxygenispresent[2].HowMetforminlinkthecancercellgrowth,proliferationandglucosemetabolismDM:DiabetesMellitus;UKPDS:UKProspectiveDiabeticisaveryinterestingareathatneedstobefurtherinvestigated.Studies;AMP
6、K:AMP-ActivatedProteinKinase;mTOR:Thisreviewdiscussesthehistoryandproposedanti-cancerMammalianTargetOfRapamycin;ROS:ReactiveOxygenSpecies;mechanismsofmetforminandsummarizestheepidemiologicalADVANCE:theActioninDiabetesandVascularDisease:Preteraxdataandobservationalandprospectiveevi
7、denceofanti-cancerandDiamicron-MRControlledEvaluation;ACCORD:Actioneffectofmetformin.toControlCardiovascularRiskinDiabetes;VADT:VeteransAffairsDiabetesTrial;PROactive:PROspectivepioglitAzoneHISTORYClinicalTrialInmacroVascularEvents;RECORD:RosiglitazoneFoundinFrenchlilac(Galegaoffi
8、cinalis),MetforminwasfirstEvaluat
