脑脊液检测

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1、JNeurooncol(2012)109:239–244DOI10.1007/s11060-012-0908-2LABORATORYINVESTIGATIONMicroRNAsincerebrospinalfluidasbiomarkerfordiseasecoursemonitoringinprimarycentralnervoussystemlymphomaAlexanderBaraniskin•JanKuhnhenn•UweSchlegel•WolfSchmiegel•StephanHahn•RolandSchr

2、oersReceived:6March2012/Accepted:29May2012/Publishedonline:23June2012ÓSpringerScience+BusinessMedia,LLC.2012AbstractDiagnosisofprimarylymphomasofthecentraltocontrols.Insummary,thisstudyprovidesthefirstevi-nervoussystem(PCNSL)largelydependsonhistopathol-dencethat

3、CSFmiRNAshavethepotentialasbiomarkersogyoftumorbiopsies.Recently,weidentifiedmiRNAsfortreatmentmonitoringanddiseasefollow-upofpatientsdetectedintheCSFofPCNSLpatientsasnovelnon-withPCNSL.invasivebiomarkersforthisdisease.IncombinedanalysesofmiR-21,miR-19b,andmiR-9

4、2CSFlevels,itwaspos-KeywordsPrimarycentralnervoussystemlymphoma
sibletodifferentiatePCNSLfromotherneurologicaldis-Cerebrospinalfluid(CSF)
Serum
MicroRNA(miRNA)
orders.Inthecurrentstudy,wefirstconfirmedourpreviousDiseasecoursefindingsinanenlargedPCNSLcohort(n=39;sen

5、sitivity97.4%).Also,wesoughttoestablishthepotentialroleofCSFmiRNAsasbiomarkersfordiseasecoursemonitoring.IntroductionInsequentialmiRNAmeasurementsinCSFderivedfromninepatientswithdifferentdiseasecourses,anintriguingPrimarylymphomasofthecentralnervoussystemcorrel

6、ationofmiRNAlevelsandPCNSLstatusduring(PCNSL)representasubcategoryofextranodalnon-treatmentand/ordiseasefollow-upwasdemonstrated.Hodgkinlymphomas(NHL)confinedtotheCNS[1].Finally,wedemonstratedthatmiRNAlevelsinserumofBecausePCNSLrepresenthighlyaggressivebraintumo

7、rs,PCNSLpatients(n=14)werenotelevatedascomparedearlydiagnosisisessentialforsuccessfultreatmentandpotentialimprovementofprognosis[2].StereotacticneedlebiopsyincludinghistopathologyremainsthestandarddiagnosticprocedureforpatientswithsuspectedPCNSL[3].However,defin

8、itivehistopathologicaldiagnosiscannotalwaysbeachieved,especiallyinpatientstreatedwithElectronicsupplementarymaterialTheonlineversionofthisarticle(doi:10.1007/s11060-012-0908