资源描述：
《Fantes, Grant, Pritchard - 1975 - The Regulation of Cell Size and the Control of Mitosis》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、J.theor.Biol.(1975)SO,213-244TheRegulationofCellSizeandtheControlofMitosisP.A.FANTES~,W.D.GRANT,R.H.PRITCHARD,P.E.SUDBERYANDA.E.WHEALs$DepartmentofGenetics,TheUniversity,Leicester,England(Received24April1974)Thereissu&ientexperimentalevidencetoindicatethatcellscanregulatecellsire(o
2、rnuclear~ytoplasmratio)sothatunderbalancedgrowthconditionsaconstantaveragecellsizeismaintainedoversucceedinggenerations.Thisregulationisprobablyeffectedbyalterationsinthetimingofmitosisand/orcelldivision.Generalcriteriaareestablishedtowhichanymodelmustconformwhichdescribestheregula
3、tionofcellsizeandmitosis.Itisarguedthatseveralpublishedmodelsareinconsistentwiththesecriteria.Fourgeneralclassesofmodelarepresentedwhichagreewiththesecriteria.Possibleunderlyingbiologicalbasesforthemodelsarediscussed.Mathematicaldescriptionsofeachmodelhavebeenformulatedallowingquan
4、titativeanalysisoftheirregulatoryproperties.Differentkindsofperturbationstoasteady-statecellwithequilibriumnuclear-cytoplasmicratiohaverevealeddifferentbutcharacteristicresponsemodesfordifferentmodels-immediateorasymptoticoroscillatoryapproachbacktoequilibrium.Themodelsarevalidford
5、ifferentgrowthratesandgrowthmodes.Experimentsaresuggestedwhichshouldallowthegeneralvalidityofeachmodeltobedetermined.Anexaminationofpresentavailabledatadoesnotallowaclearevaluationofanyofthemodelssincefaircomparisonbetweenpredictionandexperimentisonlyvalidunderrigorouslydefinedexpe
6、rimentalconditionsnotsofaradheredto.1.hllToductionThecellcyclemaybeconsideredasaprogressionofevents,thetimingofwhichiscorrelatedwithcellgrowth.Anumberofmodelcontrolsystemshavebeenproposedtoexplainthetimingoftheseevents,particularlytheinitiationofDNAsynthesisinprokaryotes,andtheonse
7、tofmitosisandcelldivisiontFWentaddress:DepartmentofZoology,UniversityofEdinburgh.Kin@Buildings,Edinburgh,Scotland.$Pie&taddress:DepartmentofBiologicalsciences,UniversityofAston,GostaGreen,BhinghamB47J3T,England.213214P.A.FANTESETAL.ineukaryotes.Inthispaperananalysisismadeofanumbero
8、fbothoriginalandexistingmo
