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1、SkinabsorptionofaromaticaminesPercutaneousabsorptionofaromaticaminesandtheriskassessmentresultingfromthedermalpathwayGintautasKorinth1,KarlHeinzSchaller1,HansDrexler11InstituteandOut-PatientClinicofOccupational,SocialandEnvironmentalMedicine,UniversityErlangen-Nuremberg,Schillerstrasse2
2、5/29,91054Erlangen,GermanyTABLEOFCONTENTS1.Abstract2.Introduction3.Skinbarrieragainstchemicals4.Methodsfortheinvestigationofpercutaneousabsorption5.Percutaneousabsorptionofaromaticamines5.1.Quantificationofpercutaneousabsorption5.2.Influenceofphysicochemicalpropertiesofaromaticaminesonp
3、ercutaneousabsorption5.3.Influenceofdoseandvehicleonpercutaneousabsorption5.4.Dermalmetabolismofaromaticamines5.5.Percutaneousabsorptionanddermalmetabolismofazodyes5.6.Influenceofpersonalprotectiveequipmentonpercutaneousabsorption6.Riskassessmentfrompercutaneousabsorption7.Summaryandper
4、spective8.References938Skinabsorptionofaromaticamines1.ABSTRACTAromaticamines(AA)arecompoundsofdifferentcarcinogenicpotencycausingoccupationalbladdercancer.ThepercutaneousabsorptionofAAismostlyappraisedtobehigh.ManyAAare,therefore,assignedwithskinnotations.However,fortheassessmentofthed
5、ermalexposurerouteonlylittledataareavailable.Additionally,inmanystudiestheskinpenetrationdataforAAareprovidedasabsorbedpercentageofapplieddoseorpermeabilitycoefficients,whicharelessusefulinriskassessment.Inthisoverview,thetoxicologicalrelevanceofpercutaneousabsorptionofAAwasevaluatedand
6、apercutaneouspenetrationrankingforsomeAAisproposed.AcontinuousskinexposureofhandstoAAforafewminutescanexceedtheinhalativeexposureover8hoursatoccupationalthresholdlimitvaluesintheworkplaceair.ThehealthriskresultingfromthepercutaneousabsorptionofAAcanbeconsiderable.Alsothedermalexposureto
7、azodyes,whichcanbemetabolizedtoAA,shouldbeconsideredwithcaution.2.INTRODUCTIONAromaticamines(AA)areusedintheproductionofdyes,pharmaceuticals,pesticides,andrubber.Theyalsooccurasintermediates.AAareofspecialinterestinoccupationalmedicalhealthsurveillance,duetotheircarcinogeniceff
