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1、长托宁治疗急性有机磷中毒临床疗效的研究饶平吴国平通讯作者李乐辉林润(海南医学院附属医院急诊教研室海南海口570102)基金项目:海南省自然基金资助(编号:309068)饶平(1967-),湖北,副主任医师,木科,海南医学院附属医院急诊科,主要从事急诊内科及心血管。通信作者:吴国平,主任医师,海南医学院附属医院急诊科主任。目的:探讨长托宁治疗急性有机磷中毒患者临床疗效。方法:对三个医院98例急性有机磷中毒患者,分为两组,两组均采用常规治疗前提下,观察组采用长托宁治疗,对照组釆用阿托品治疗,治疗后对比两组的活力正常时间、用药次数、阿托品化时间、用药起效时间
2、、中毒症状消失时间、治愈情况、住院时间、不良反应等。结果:观察组治愈率959%,对照组治愈率837%,比较差异有统计学意义(P<001)。观察组在药物起效时间、阿托品化时间方面较对照组长,在症状消失,ChE恢复时间、用药次数、平均住院时间等方面,观察组较对照组少,差异有高度统计学意义(P<001)。不良反应,观察组视力模糊、口干、心动过速、躁动及尿潴留的发生率均低于对照组,差异有统计学意义(水平为001)。结论:长托宁是一种比阿托品治疗效果好,不良后应少的抗胆碱能新药。对于抢救AOPP是目前最理想抗胆碱药。【关键词】急性有机磷中毒;阿托品;长托宁;解磷
3、定ChangtuoningstudytheclinicalefficacyofthetreatmentofacuteorganophosphatepoisoningRaoPingWuGuopingLiLehuiLinrun(HainanMedicalCollegeHospitalEmergencyDepartmenthainanhaikou570102)【Abstract】Objective:ToinvestigatetheclinicalefficacyoftheChangtuoningtreatmentofpatientswithacuteorga
4、nophosphatepoisoning.Methods:Dividedintotwogroups:threehospitalsin98casesofacuteorganophosphatepoisoningpatientsinbothgroupsusingtheconventionaltherapyunderthepremiseoftheobservationgroupChangtuoningtreatment,controlgroupwithatropinetreatment,aftertreatment,comparethetwogroupsvi
5、talitytime,thenumberofdrugs,atropinetime,medicationonsettime,poisoningsymptoms,cureof,hospitalstay,adversereactions.Results:Theobservationgroupthecureratewas959%,thecontrolgroupwas837%,thedifferencebeingstatisticallysignificant(P<001).Timeofobservationgroupinthedrugeffect,atr
6、opinetimethaninthecontrolgroupinthesymptoms,ChErecoverytime,lessfrequentdosing,theaveragelengthofstayintheobservationgroupthanthecontrolgroupless,thedifferencewashighlystatisticallysignificant(P<001).Adversereactions,fuzzyobservationgroupvision,drymouth,tachycardia,agitationa
7、ndurinaryretentionwerelowerthanthecontrolgroup,thedifferencewasstatisticallysignificant(level001).Conclusion:Changtuoningthanatropinetreatmentshouldbelessbadafteranticholinergicnewdrugs.RescueAOPPisthebestanti-cholinergicdrugs.[Keywords]acuteorganophosphoruspoisoning;atropine;Ch
8、angtuoning;pralidoximeR453B1003-5028(2013)05-00