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1、西南科技大学本科生毕业论文IV黄连药用成分的提取及含量测定摘要：黄连又名为川连、川黄连、姜制黄连、姜连、萸连等。本品为毛茛科植物黄连CoptischinensisFranch、或云连CoptisteetaWall以及三角叶黄连CoptisdeltoideaC.Y.ChengetHsiao的干燥根茎。其主要功能为清热，燥湿，泻火，解毒。用于湿热，呕吐吞酸，高热神昏，心烦不寐，心火亢盛；血热，目赤，消渴，牙痛；外治湿疹，湿疮，耳道流脓；酒黄连善清上焦火热，用于目赤，口疮；姜黄连清胃和胃止呕，用于寒热互结，湿热中阻，痞满呕吐；萸黄连用于舒肝和胃止呕。本实验以含
2、量较高的活性成分盐酸小檗碱为评判指标，先对提取溶剂和提取方法进行筛选，然后以溶剂浓度、提取时间和溶剂加量为考察因素，进行用正交设计实验对黄连的提取工艺条件进行优化。结果表明，从黄连中提取盐酸小檗碱，用乙醇作为溶剂要优于甲醇、丙酮，以热回流法提取优于超声提取法。正交设计实验表明最佳提取工艺条件为3g黄连生药粉用150ml的80%乙醇提取3h。本实验通过对所筛选出的最佳工艺条件进行了验证，表明了筛选出的最佳工艺条件具有一定的可行性，并且具有较高的稳定性，而且所提取的有效成分含量也比其他方法高。关键词：黄连;盐酸小檗碱;正交设计;最佳工艺;含量西南科技大学本科
3、生毕业论文IVExtractionandAssayingofMedicinalingredientsInRhizomaCoptidisAbstract:Huanglianisnamedchuanlian,chuanhuanglian,jiangzhihuanglian,jianglian,yulianandsoon.TheBranchofhuanglianisRanunculaceaeCoptischinensisFranchorCoptisteetaWallandCoptisdeltoidea.Themajorfunctionofhuanglianis
4、clearingheart,eliminatingdampnessdischargingfiredetoxify.Usedformuggy,sicknessandacidregurgitationhyperpyrexia,coma,fussandsleepness,heart-fire,hyperactivity;blood-heart,hot-eyes,drinkingandurine,toothache;italsousedforeczema,auditorymeatussuppurate;jiuhuanglianisgoodatclearingup
5、per-heaterfiery,usedforhot-eyes,,canker;jianghuanglianisusedforclearingstomacheandcontrollingnauseaandvomiting,besides,chillsandfeverinterties;yuhuanglianisusedforrelaxingliver,controllingnauseaandvomiting.Inthisexperimentwithhigherlevelsoftheactiveingredientofberberinehydrochlor
6、ideforevaluationindicators,Firstscreeningtheextractionsolventandextractionmethods,Andthenwiththedissolventconcentration,dissolventvolumeandextractiontimeforthestudyoffactorstooptimizedextractionconditionsofhuanglianbyorthogonaltest.TheresultsshowedthatTheberberinehydrochlorideext
7、ractedfromhuanglian,ethanolissuperiortomethanol,acetoneasasolvent,heatrefluxextractionmethodissuperiortoultrasonicextractionmethod.Theoptinmmextractionprocessesofextractingberberinehydrochloridefromhuanglianwasadding150mlof80％alcohol，refluxingandextracting3hourfor3g.Thisexperimen
8、tverifytotheoptimumconditions,showedthat
