资源描述：
《血浆五聚素3及冠心病及冠脉病变严重程度相关性探究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、血浆五聚素3及冠心病及冠脉病变严重程度相关性探究[摘要]目的:探讨血浆五聚素3(PTX3)与冠心病发生、发展的相关性,并根据冠脉造影了解其与冠脉严重程度是否相关。方法：100例受试者分为正常对照组20例,稳定型心绞痛(SAP)组20例,不稳定型心绞痛(UA)组30例,急性心肌梗死(AMI)组30例,冠心病3组患者均行冠脉造影检查,并分别检测各组入院第2天血浆PTX3、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)和超敏C反应蛋白(hs-CRP)等生化指标,并进行
2、比较。冠心病3组患者按Gensini标准对冠状动脉病变程度进行积分,了解PTX3水平是否与冠状动脉严重程度相关。结果：SAP组与正常对照组之间PTX3水平差异无统计学意义(P>0.05),UA组和AMI组PTX3水平高于SAP组和正常对照组(P0.05)。经Spearman相关分析表明,冠状动脉病变严重程度与PTX3水平无明显相关性,而血浆脂质成分指标与冠脉病变程度的相关性似乎更加密切。结论：PTX3水平与冠心病临床分型的轻重程度有相关性,而与冠状动脉严重程度无明显相关性。［关键词］血浆五聚素3；冠心病
3、；冠状动脉造影［中图分类号］R541.4［文献标识码］A［文章编号］1671-7256(2011)02-0134-0512doi：10.3969/j.issn.1671-7256.2011．02.004Studyontherelationshipbetweentheplasmapentraxin3andcoronaryarterydiseases,andtheseverityofcoronaryarterylesionsWANGQiang，SUNJian-hui，WANGMeng-fei，DAIGui-
4、jun（DepartmentofCardiovascular,theThirdAffiliatedHospitalofSuzhouUniversity,Changzhou213003,China)［Abstract］Objective:Toevaluatethecorrelationbetweenpentraxin3levelsandtheoccurrence,evolutionofcoronaryarterydiseases,andexploretherelationshipbetweenpentra
5、xin3levelsandcoronaryarterylesionaccordingtoangiography.Methods:100subjectsweredividedintonormalgroup(n=20),SAPgroup(n=20),UAgroup(n=30)andAMIgroup(n=30).Thethreegroupsofcoronaryarterydiseaseunderwentangiography.Thepentraxin3levelsofeachgroupaswellasTG,T
6、C,LDL-C,hs-CRPandFBGweredetectedontheseconddayofadmission.AccordingtoGensinistandard,criteria12pointswerecalculatedtothethreegroupsofcoronaryarterydiseaseswerecalculatedtounderstandwhetherthePTX3levelscorrelatedwiththeseverityofcoronaryarterylesions.Resu
7、lt:ThedifferentPTX3levelsbetweentheSAPgroupandnormalgroupwerenotstatisticallysignificant(P>0.05).ThePTX3levelsinUAPgroupandAMIgroupweresignificantlyhigherthanthoseoftheothertwogroups(P0.05).Thespearmancorrelationanalysisshowedthattherewasnotasignificantc
8、orrelationbetweenPTX3levelsandtheseverityofcoronaryarterylesions.Buttheplasmalipidandthecoronaryarterylesionappearedtobemorecloselyrelated.Conclusion:ThePTX3levelswerecorrelatedwithseverityofclinicalclassificationincoronar
