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ID:15122186
大小:35.50 KB
页数:10页
时间:2018-08-01
《中药方剂联合氯氮平治疗慢性精神分裂症对照研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、中药方剂联合氯氮平治疗慢性精神分裂症对照研究作者:崔界峰宋崇顺韩卫军【摘要】目的探讨中药方剂联合氯氮平治疗慢性精神分裂症的临床疗效及安全性。方法将60例慢性精神分裂症患者随机分为两组各30例,两组均给予氯氮平治疗,研究组联合中药方剂治疗,对照组联用外观与中药方剂完全相同的安慰剂治疗。观察16w。于治疗前及治疗第4w、8w、12w、16w末采用简明精神病量表、阴性症状量表评定临床疗效,副反应量表评定不良反应。结果治疗16w末研究组显效率为43.3%,对照组为13.3%(χ2=4.86,P<0.05)。简明精神病量表及阴性症状量表评分,研究组治疗8w末起,对照组治疗1
2、2w末起较治疗前有显著性下降(P均<0.01),且随治疗时间的延续均呈持续性下降;简明精神病量表评分研究组总分及焦虑抑郁、缺乏活动、思维障碍、自知力因子分均较对照组下降显著(P<0.05或0.01);阴性症状量表评分研究组总分及各因子分均较对照组下降显著(P<0.05或0.01)。研究组不良反应发生率显著低于对照组。结论中药方剂联合氯氮平等抗精神病药物是一种安全、有效的治疗慢性精神分裂症的方法。【关键词】中药方剂;氯氮平;精神分裂症;阴性症状10 AcontrolstudyofChinesemedicinalformulaeincombinationwithcl
3、ozapineinchronicschizophrenia 【Abstract】ObjectiveToexploretheclinicaleffectsandsafetyofChinesemedicineformulaeincombinationwithclozapineinchronicschizophrenia.Methods60chronicschizophrenicswererandomlydividedintoresearchgroup(n=30)receivingclozapineplusaChinesemedicineformulaeandcont
4、rolgroup(n=30)plusplacebowhichwasidenticaltotheChinesemedicineformulaeinappearancefor16weeks.ClinicalefficacieswereassessedwiththeBriefPsychiatricRatingSacle(BPRS)andtheScaleforAssessmentofNegativeSymptom(SAPS)andadversereactionswiththeTreatmentEmergentSymptomScale(TESS)beforetreatmen
5、tandattheendsofthe4th,8th,12thand16thweek.ResultsAttheendofthe16thweek,excellencerateswere43.3%intheresearchgroupand13.3%inthecontrolrespectively(P<0.05).ThescoresoftheBPRSandtheSAPSloweredmoresignificantlysincetheendofthe8thweekintheresearchandsincetheendofthe12thweekinthecontrolg
6、roupcomparedwithpretreatment(bothP<0.01)anddidcontinouslyalongwithtimeoftherapylasting;theBPRStotal,anxietydepression,absenceof10activity,thoughtdisturbanceandinsightscore(P<0.05or0.01)andtheSAPStotalandallfactorscoreloweredmoresignifivantlyintheresearchthaninthecontrolgroup(P
7、<0.05or0.01).Theincidencesofadversereactionsweresignificantlylowerintheresearchthaninthecontrolgroup.ConclusionChinesemedicineformulaeplusclozapingissafeandeffectiveinthetreatmentofchronicschizophrenia. 【Keywords】Chinesemedicineformulae;clozapine;schizophrenia;negativesymptom 精神分
8、裂症是一种
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