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1、中国组织工程研究与临床康复第14卷第41期2010–10–08出版JournalofClinicalRehabilitativeTissueEngineeringResearchOctober8,2010Vol.14,No.41成骨蛋白1在椎间盘退变和修复中的作用★121刘航涛，王万明，林智军Roleofosteogenicprotein-1indiscdegenerationandrepair121LiuHang-tao,WangWan-ming,LinZhi-junAbstract1BACKGROUND:Howtoregenerationandrepairintervertebra
2、ldiscspuzzlesdoctorsinorthopedics.WithastrongosteoinductiveDepartmentofOrthopaedics,Firstactivity,osteogenicprotein-1caninduceboneandcartilageformationinvivo.HospitalofFuzhouOBJECTIVE:Tosummarizeanddiscusstheeffectsofosteogenicprotein-1ondiscdegenerationandrepair.GeneralHospitalofNanjingMilitary
3、AreaMETHODS:DatabasesofChinaJournalofFull-textDatabase(CNKI)andPubMedweresearchedbythefirstauthorusingkeyCommandofwordsof“intervertebraldisc;degeneration;osteogenicprotein-1/bonemorphogenicprotein-7”tofindpaperspublishedbetweenChinesePLA,Putian1990and2010bothinChineseorEnglish.Theeffectsofosteog
4、enicprotein-1onintervertebraldisccellsanditsdegeneration351100,FujianProvince,China;bothinvitroandinvitrowereintroduced.2DepartmentofRESULTSANDCONCLUSION:Totally56paperswereretrievedbycomputer,and27documentswereselectedaccordingtotheOrthopaedics,inclusiveandexclusivecriteria.Asaresult,osteogenic
5、protein-1hasaneffectonpromotingdisccellssynthesizingcollagenandFuzhouGeneralHospitalofNanjingproteoglycan,canadjustandrestoratethemetabolismofextracellularmatrixindiscdegeneration,andshowsabrightfuturetoMilitaryArearetarddiscdegeneration.CommandofChinesePLA,Fuzhou350025,LiuHT,WangWM,LinZJ.Roleof
6、osteogenicprotein-1indiscdegenerationandrepair.ZhongguoZuzhiGongchengYanjiuyuFujianProvince,LinchuangKangfu.2010;14(41):7731-7734.[http://www.crter.cnhttp://en.zglckf.com]ChinaLiuHang-tao★,摘要Master,Physician,背景：椎间盘的再生修复是当前骨科疾病治疗所面临的一个难题，而成骨蛋白1具有强大的骨诱导活性，能够在体内诱导骨DepartmentofOrthopaedics,First和软骨形
7、成。HospitalofFuzhou目的：总结并讨论成骨蛋白1在椎间盘退变和修复中的作用。GeneralHospitalofNanjingMilitaryArea方法：由第一作者用计算机检索中国期刊全文数据库(CNKI：1990/2010)和Pubmed数据库(1990/2010)，检索词分别为“椎Commandof间盘，退变，成骨蛋白1/骨形态发生蛋白7”和“intervertebraldisc，degeneration，osteogenic
