资源描述：
《高同型半胱氨酸血症对球囊损伤大鼠颈动脉核转录因子nf论文》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、高同型半胱氨酸血症对球囊损伤大鼠颈动脉核转录因子NF论文徐会圃，刘长梅，冯义柏【关键词】,甲硫氨酸EffectofhomocysteineonexpressionsofNFκBandprotooncogeneinballooninjuredratcarotidarteries【Abstract】AIM:Tostudytheeffectofhomocysteine(Hcy)ontheexpressionsofnuclearfactorκB(NFκB)P65proteinandcfos,cjunmRNAinmoncarotidarteryofratsafterballooninjuryandt
2、oexplorethepossiblemechanismbyocysteineexacerbatesneointimalhyperplasiaafterangioplasty.METHODS:TheexpressionsofNFκBP65proteinandcfosandcjunmRNAiquantitativeRTPCRrespectivelyinthemoncarotidartery.RESULTS:TheexpressionsofNFκBP65proteinandcfosandcjunmRNAethionine(LM)group（1.12±0.13,1.40±0.21,1.43±0.
3、25）（P0.05）andhighmethionine(HM)group（1.50±0.37,1.68±0.27,1.71±0.30）（P0.01）thanthoseincontrolgroup（0.64±0.06,1.10±0.15,1.00±0.13）.TheexpressionsofNFκBP65proteinandcfos,cjunmRNAocysteinemayupregulatethetranscriptionofcfosandcjunmRNAinmoncarotidarteryafterballoonangioplastybyNFκBpathayberesponsiblefo
4、rneointimalhyperplasiainducedbyhomocysteineafterangioplasty.【Keyethionine;homocysteine;ballooninjury;NFkappaB;protooncogenes【摘要】目的：观察高蛋氨酸饮食诱导的高同型半胱氨酸血症对大鼠颈动脉球囊损伤后血管组织NFκBP65蛋白和原癌基因cfos及cjunmRNA表达的影响，探讨同型半胱氨酸在血管球囊损伤后新内膜过度增生中的可能机制.方法：采用ethodsandclinicalapplication［J］.ClinChem,1993,39(9):1764-1779.［4
5、］徐会圃，冯义柏.高同型半胱氨酸血症对大鼠颈动脉损伤后新内膜增生的影响［J］.中国康复医学杂志，2004,19（2）:115-117.［5］MianoJM,VlasicN,TotaRR,etal.Smoothmusclecellimmediateearlygeneandgrob,1993,13(2):211-219.［6］KarinM.TheregulationofAP1activitybymitogenactivatedproteinkinases［J］.JBiolChem,1995,270(28):16483-16486.［7］ZhuJ,MixE,OlssonT,etal.Cellul
6、armRNAexpressionofinterferongamma,IL4andtransforminggroononuclearcellsstimulatedyelinantigensinexperimentalallergicneuritis［J］.ClinExpImmunol,1994,98(2):306-312.［8］ulatesnuclearfactorkappaBactivityandmonocytechemoattractantprotein1expressioninvascularsmoothmusclecells:Apossibleroleforproteinkinase
7、C［J］.BiochemJ,2000,352(Pt3):817-826.
