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ID:37457856
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页数:7页
时间:2019-05-24
《不同剂量硒对染铅孕鼠仔代生长发育影响》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、不同剂量硒对染铅孕鼠仔代生长发育影响【摘要】目的探讨不同剂量硒对染铅孕鼠仔代性别分化、生长发育和青春期启动的影响。方法SD大鼠随机分为5组,自受孕1~20d,中毒组孕鼠自由饮用含2mg/ml醋酸铅的双蒸水,硒拮抗组在此基础上分别自由饮用含2,4,8μg/ml亚硒酸钠的双蒸水,对照组自由饮用双蒸水。自然分娩后各组母鼠均饮用双蒸水并哺乳,观察仔鼠性别比例、出生后4,22d生存率、肛殖距离(AGD)和青春期启动的情况。结果4μg/ml硒拮抗组仔鼠的生长发育和青春期启动与对照组比较差异无统计学意义(P>0.05),各组仔鼠的性别比例和肛殖距离差异无统计学意义
2、(P>0.05)。结论4μg/ml亚硒酸钠可明显拮抗2mg/ml醋酸铅对仔鼠生长发育和青春期启动的毒性,孕期适宜的硒营养补充量可明显改善有铅暴露史孕鼠仔代的生长发育和青春期启动。【关键词】铅硒性别分化生长发育青春期启动EffectofseleniumongrowthanddevelopmentofleadintoxicatedpupratsWANGJuan,MengHuanping,YINJie,etal.DepartmentofGynaecologyandObstetrics,theFourthAffiliatedHospital,HebeiM
3、edicalUniversity(Shijiazhuang050011,China)Abstract:ObjectiveToaverttheeffectofvariousdosesofseleniumonlead-inducedsexdifferentiation,growthanddevelopmentofpubertyofthepuprats.MethodsSDratswererandomlydividedinto5groups.FromGD1toGD20,theleadpoisoninggroupratswerefed2mg/mlleadace
4、tatesolutionbydrinking.Theselenium-rivalrygroupratswerefed2,4,8μg/msodiumselenitesolutionbydrinkingonthebase.Thecontrolgroupratsdrinkdoubleevaporatedwaterrandomly.Afterdelivery,allmotherdrunkdoubleevaporatedwaterrandomlyandsuckling.Itwasobservedthatthesexdifferentiation,surv
5、ivalrateatPND4andPND2,AGDanddevelopmentofpubertyofthepuprats.ResultsThegrowthanddevelopmentofpubertyofthepupratshadnosignificantdifferencebetweenMAgroupandcontrolgroup(P>0.05).TherewasnosignificantdifferenceinthesexdifferentiationandAGOamongallgroups(P>0.05).Conclusion4μg/ml
6、sodiumselenitecanprovidesignificantprotectiveeffectstothehazardsofthe2mg/mlleadacetateonthegrowthanddevelopmentofpubertyofthepuprats.Theselenium'seligibleadditioninpregnancycanimprovethegrowthanddevelopmentofpubertyofthesecondgenerationobviously.Keywords:lead;seleniun;sexdiffer
7、ence;growthanddevelopment;pubertyintiation随着现代工业及交通业发展,铅对环境的污染日趋严重。铅通过呼吸道、消化道及皮肤吸收后,对机体的影响是全身性、多系统的,胎儿及新生儿因其独特的生理发育特点对铅的毒性更为易感〔1〕。近年来,硒对铅毒性的拮抗作用成为研究热点之一。本实验旨在探讨不同剂量硒对染铅孕鼠仔代性别分化、生长发育及青春期启动的影响,从而为临床选择最适宜的硒营养补充量提供实验依据。1材料与方法1.1动物与妊娠标准成年SD大鼠共80只,其中雌鼠50只,雄鼠30只,体重240~270g,饲养环境温度为(20±
8、2)℃,湿度为(50±20)%,昼夜周期为12/12h。雌性SD大鼠与雄性SD大鼠以2:1比例同笼,次日上午
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