SNAIL蛋白表达与肝细胞癌术后预后的相关性研究

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1、肝胆外科杂志2010年4月第18卷第2期JournalofHepatobiliarySurgery，Vol，18，No．2，Apr．2010131·基础研究·Snail蛋白表达与肝细胞癌术后预后的相关性研究夏勇，李俊，施乐华【摘要】目的研究Snail蛋白在肝细胞癌(HCC)中的表达及其与临床病理特征和术后预后的关系。方法应用免疫组织化学sP法，检测Snail蛋白在103例肝细胞癌及25例正常肝组织中的表达及其在细胞中的定位。结果Snail蛋白高度表达于肝癌组织的细胞核、细胞质，正常肝组织中表达较少甚至不

2、表达，阳性率分别为51．5％和16％，两者差异有统计学意义(P<0．05)。Snail在肝癌中的高表达与肝癌的pTNM分期、肿瘤有无包膜和微血管侵犯有关(P<0．05)。结论HCC患者的术后的预后与Snail蛋白的表达有关，Snail蛋白有可能成为肝癌术后预测复发判断预后的生物学标志。【关键词】肝细胞癌，预后，生存，蛋白表达，Snail蛋白【中图分类号】R735．7【文献标识码】A【文章编号】1006-4761(2010)02-0131-03RELATIONSHIPBETWEENSNAILPROTEIN

3、EXPRESSIoNANDPROGN0SISOFHEPAToCELLULARCARCINO-MAAFTERHEPATECTOMY(XIAy0，LIJun，SHILe—hua．TheFirstDepartmentofComprehensiveTreatment，EasternHepa—tobiliarySurgeryHospital，SecondMilitaryMedicalUniversity，Shanghai200438，China)【Abstact】ObjectiveToresearchtheexp

4、ressionofSnailproteininHepatocellularCarcinama(HCC)anditscorrelationwiththec1inicopath0localcharacteristicsandprognosisafterhepatectomy．MethodsImmunohistochemicalSPmethodwasusedtoassesstheexpressionofSnailproteinin103easesofHCCtissuesand25casesnormallive

5、rtissues．TheclinieopathologicalfeaturesofHCCwerealsocollectedandquantified．TherelationshipbetweenSnailproteinexpressionandprognosisaftersurgerywasinvestigated．Re-suitsSnaillocatedmainlyinplasmaofHCCcells．SnailhadhigherexpressioninHCCandalmostnoexpression

6、innormaltissue．ThepositiverateofSnailinHCCwas51．5％，whichwassignificantlyhigherthanthatinnormallivertissue(16％，P<0．05)．Theexpres—sionofSnailinHCCwassignificantlyrelatedwithpTNMstaging，with／withouttumorcapsule，andwith／withoutmicrovascularinvasion(P<0．05)．T

7、he5-yearoverallsurvivalratewassignificantlowerintheHCCcaseswiththepositivelyexpressionofSnailthanintheHCCcaseswithnegativelyexpression(P<0．05)．ConclusionTheprognosisandoverallsurvivalarecorrelatedwiththeexpressionofSnailprotein．Snialmightbeanimportantbio

8、logicalmarkerforprognosisofHCCaftersurgery．【Keywords】hepatocellularcarcinoma；prognosis；survival；proteinexpression；snail对肝细胞癌(HepatocetlularCarcinoma，HCC)术后复发完整以病理结果结合影像学和术中情况确定；血清HBsAg、的研究一直是肿瘤研究的热点。Snail蛋白是近年发现的锌AFP水平以临床检