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1、DevelopmentofSurvivinandTumorResearchJIYu-bin1,2,3,LIUGuang-da*1,YULei1,2,3,LIHai-jiao1,YANGHai-fan1，PANGLin-lin1（1CenterofResearchandDevelopmentonLifeSciencesandEnvironmentalSciences,HarbinUniversityofCommerce,Harbin150076,China;2.InstituteofMateriaMedicaan
2、dPostdoctoralProgrammeofHarbinUniversityofCommerce,Harbin150076,China;3.EngineeringReseachCenterofNaturalAnticancerDrugs,MinistryofEducation）Abstract：ObjectiveSurvivinwasfirstlyseparatedinhybridizationofEffectorCellProteaseReceptor-1(EPR-1)cDNAinhumangenomeb
3、yYaleUniversity'sAmbrosiniin1997,whichismemberoftheinhibitorofapoptosisproteins(IAPS).UnlikeotherIAPprotein,foundduringembryonicandfetaldevelopment,survivinwascompletelydown-regulatedandundetectableinnormaladulttissues,andbecameprominentlyreexpressedinalloft
4、hemostcommoncancers.Itthroughincludesthecysteine/histidinerod-shapedviralIAPrepetitionsequencebaculoviralIAPrepeats(BIRs)thestructureterritorydirectlyorintervenesCaspasesthefunctiontodisplayindirectlyitsanti-perishesweaklythefunction,simultaneouslyitalsoisin
5、thecelldivisionprocessthechromosometravelerprotein(chromosomepassengerprotein).Therearethreeapproachesbywhichsurvivininhibitstheprocessingofapoptosis:(1)inhibitsprocessingofdownstreameffectorcaspase-3,caspase-7andcaspase-9incellreceivingapoptoticstimuls.(2)w
6、iththeSmac/DIABLOfunction,sendstheXIAPactivenesstoincrease,XIAPthroughdirectlyaffectsandrestrainsitsfunctionwithcaspases,achievedrestrainsfunctionwhichperishesweakly;(3)throughrestrainsp53thefunctiontoblockperishesweaklytheprocess.Survivinexpressedspecificit
7、yanditsfunctionmultiplicity.Survivinonlyexpressesintumortissuesandcannotbefoundinnormalterminallydifferentiatedtissues.ThiskindofexpressionisbeenextremelylowthecellcyclestrictregulationintheG1timeexpression,theStimeisG1time6times,theG2/Mtimeadvancesto40times
8、,demonstrateditsexpressionhastheG2/Mtimedependencespecificity.Ithasbi-functionofinhibitingapoptosisandinvolvingincellcyclecontrol.Survivinhasfoundinmostoftumorcellsinrecentlyresearches.Survivine
