片仔癀临床研究英文版

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1、AclinicaltrialofcombineduseofPienTzeHuangandTACEinthetreatmentofprimarylivercancerShui-lianZHAOJiePIANZhangzhouPienTzeHuangPharmaceuticalCo.Ltd.ZhangzhouFujian363000,China*E-mail:pzhzsl@126.comAbstract:Objcctivcs:WcaimedtoinvestigatethetherapeuticeffectofcombinedusageofPienTzeHuang(PTH

2、)onthetreatmentofprimarylivercance匚Method:ThisPhaseIIrandomized,double-blind,placebo-controlledclinicaltrialenrolled240patientswithprimarylivercancer.PatientswererandomizedtoreceiveeitherTACEandPTHorTACEandplacebo.PTHgroupwasprescribedto2pills(for3timesaday),for2cyclesof4weeks・102cases

3、inPTHgroupand105casesinplacebogroupwereusedforstatisticalanalyses・TheenhancingeffectofPTHonanti-tumorigenesiswasassessed.Results:AstatisticallygreaterproportionofthePTHgroupthantheplacebogrouphadimprovementsintumorsizeshrinkage,qualityoflife,painreliefandtherapeuticeffect.Moreover,thes

4、ideeffectsinducedbychemotherapysuchasloweringofleukocyteslevels,vomiting,increasedALT,ASTenzymewereimprovedinthePTHgroup.Conclusion:ThecombinedusageofPienTzeHuangandTACEimprovethetherapeuticeffectonthetreatmentofprimarylivercancerKeywords:PienTzeHuangcapsuleprimarycarcinomaoftheliverTA

5、CEclinicalNotice:PZHgroup=TACE+PZH,Control=TACE+placebo,Before=BeforethetreatmentAfter=AfterthetreatmentResults:1、Thegeneralefficacy:TheresponserateofthePZHgroupwas85.3%.Theresponserateofthecontrolgroupwas59.0%.■PZHgroup■Control2、Chinesemedicinesymptomtotalintegralio

6、PZHgroup□ControltreatmenttreatmentAfterthetreatment,theimprovementofChinesemedicinesymptominthePZHgroupwasbetterthanthatinthecontrolgroup・3、Thequalityoflife100厂BeforethetreatmentAfterthetreatment■PZHgroup■controlAfterthetreatment,thequalityoflifewassignificantlyincreasedinthePZHgroup.4

7、、Afterthetreatment,tumorsizewassignificantlydecreasedCM2rPZHgroup■ControlAfterthetreatment,turnersizeinthePZHgroupwasdecreasedsignalerthanthatinthecontrolgroup,turnersizeshrinkageinthePZHgroupwas50%・5、Afterthetreatment,theAFPinserumwasdecreasedooooooooooooooooooooooooooooooo086420864