健康人群甲状腺自身抗体与甲状腺功能的关系

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1、万方数据·324尘堡囱坌鲨垡塑苤查!!!!生兰旦笙望鲞笙!塑垦塑!!堡!!!型!!!堕!!坐!垒巳!

2、!!!!!，!丛!!!型0．兰健康人群甲状腺自身抗体与甲状腺功能的关系董作亮林来祥孙毅娜史凯斌阎玉芹·临床研究·【提要】探讨我国8～10岁学龄儿童、成人、孕妇和哺乳期妇女的甲状腺自身抗体与甲状腺功能关系，为甲状腺疾病的预防监测提供参考。在6个碘盐供应较好的省份一次性横断面调查_r健康8～10岁学龄儿童、成人、孕妇和哺乳期妇女各693、698、325、332名；采用全自动化学发光免疫分析法检测血清‘FSH、FT，、FT；，放射免疫法检测甲状

3、腺自身抗体抗体检测结果显示，女性甲状腺自身抗体阳性率明显高于男性，表现为学龄儿童：5．6％对2．O％，成人：22．8％对3．2％：但孕妇和哺乳期妇女抗体阳性率(8．9％，8．7％)明显低于普通成年女性(22．8％)、抗体阳性者甲状腺功能异常率高于抗体阴性者，均以亚临床甲状腺功能减退为主。另外，发现哺乳期妇女抗体阴性者，其甲状腺功能异常率也较高．但以低Fvr．为主。、甲状腺功能异常与甲状腺自身抗体阳性有关，应加强甲状腺自身抗体阳性者的随访和监测，以利于甲状腺疾病的预防和临床早期诊治。应尽快建立哺乳期妇女甲状腺功能正常参考值范围。【关键词】学

4、龄儿童；成人；孕妇；哺乳期妇女；甲状腺自身抗体；甲状腺功能TherelationshipbetweenthyroidautoantibodiesandthyroidfunctionindifferentpopulationsDONGZun—liang‘，LINk如一xiang，SUNYi—na，SHIKai-btn，YANYu-qin．’MedicalLaboratory，GeneralHospital，TtnwiHMedicalUniversit)‘，Tianji．300070，ChinaCorrespondingauthor：¨，vY

5、u—qin，Email：yan)uqin2005@yahoo．COtrl．CII【Summary】ToexploretherelationshipbetweenthyroidautoantibodiesandIhyroidfunctioninschoolchildrenaged8-10years，aduhs，pregnantwomen，andla(’tatingwomeninChina，inordertopl‘{)viderefereneeforthepreventionandmonitoringofthyroiddisease．Heal

6、thy8-10yearsoldschoolchildren(693eases)，a(1tdts(698(rases)，pregnantwonlen(325cases)，andla(-taringwomen(332cases)fromsixieditlesuffit·tentareaswe!‘eenrolled．SerumTSH，FYI．。，andFTlweredeterminedhychemihminescentimmunoassay，whileantithyroidantil){)(tyhymdioinlmunoassav．Thepos

7、itiverate('fthyroidautoantibodiesinfemaleswassignific·antlyhigherthanthatinthemale(5．6％VS2．0vk,insrheelc1)ildren，and22．8％1：53．2％ina(1ults)；whilepnsitiverateofautoantil)odiesinpregnantandlactatingwomen(8．9％．8．7％)weresignificantlylowerthanthatintheotherlleallhvadultwomen(22

8、．8％)．Theincidenceofabnormalthyroidfun(‘tioninantibod)7一positivepeoplewashigherthanthatinnegativeonesinallgroups，andabnormalthyroidfunctionshowedmainlyassu])clinicalhypothyroidism．Ina(hlitton，lactatingwomenwithnegativeautoantibndiespresentedahigherincidem·eofabnol'nlalthyr

9、oidfunction，mainlyaslowvrj．7rheabnormalthyroidfun(‘lionisrelatedwiththepositivethyroidautoantil)