3、eutrophil cytoplasmic autoantibodies.Report of 4 cases and review of literaturesLIU Na,ZHAO Minghui,ZHANG Youkang,et al.Institute of Nephrology,First Hospital of Beijing Medical University,Beijing 100034 【Abstract】 Objective To study patients with coexisting anti-glomerular basement membrane a
4、ntibodies(Anti-GBM)and anti-neutrophil cytoplasmic autoantibodies(ANCA),and to analyze their clinical and pathological features.Methods 68 sera from 68 patients with Anti-GBM and/or ANCA(MPO or PR3-ANCA)related diseases were collected and were further tested for Anti-GBM and ANCA respectively.T
5、he clinical and pathological features of patients with coexisting Anti-GBM and ANCA were analyzed.Results Of the 17 sera with Anti-GBM，55 sera wtih ANCA,4 sera had both Anti-GBM and ANCA (3 MPO-ANCA，1 PR3-ANCA)，which represented approximately 24% of the Anti-GBM positive population and 7% of t
6、he ANCA positive patients.Of the 4 patients with both antibodies,they tended to have multi-system involvement.Renal pathology showed crescentic glomerulonephritis,direct immunofluorescence demonstrated fine granular localization of IgG and C3 along GBM.The prognosis of this type of patients was
7、 poor despite intensive therapy.Conclusion Patients with coexisting Anti-GBM and ANCA tended to have multi-system involvement,similar to those with ANCA positive alone.The prognosis of these patients was poor,similar to patients w
