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1、不孕和反复自然流产患者解脲支原体及沙眼衣原体感染的分析【摘要】目的研究原发性不孕症、继发性不孕症及反复自然流产与解脲支原体(UU)、沙眼衣原体(CT)感染的相关性。方法收集原发性不孕、继发性不孕、曾多次自然流产病例及有生育能力健康女性(对照)之宫颈拭子,用PCR方法作UU及CTDNA定量检测后比对分析。结果原发性不孕、继发性不孕、反复自然流产及对照组的UU、CT及CT+UU阳性率分别为：48.9%、44.3%、17.0%，52.4%、47.6%、21.4%，51.8%、46.4%、19.7%及10.0%、6.7%、0.00%。原发性不孕症、继发性不孕症及反复自然流产组的UU和CT阳性率、CT+
2、UU混合感染率均明显高于对照组(P<0.01或0.05)，而3者之间相比无明显差异。对于UU和/或CT阳性的患者经治疗后，原发性不孕症、继发性不孕症及反复自然流产组分别有19.3%、21.4%及23.2%妊娠并生育，三者相比差异无统计学意义。结论UU、CT感染是引起不孕症及自然流产的重要病因之一。【关键词】不孕症反复自然流产解脲支原体沙眼衣原体CorrelationofinfertilityandrepeatedabortionwithUreaplasmaurealyticumandChlamydiatrachomatisinfection.CHANGLe,YANGShu-ying,HEGuo
3、-li,etal.(HainanProvincialPeople’sHospital,Haikou570311,Hainan,P.R.China)Abstract：ObjectiveToanalyzethecorrelationofinfertilityorrecurrentabortionwithofUreaplasmaurealyicam(Uu)andChlamydiatrachomatis(CT)infection.MethodsThere88primaryinfertilitycases,42secondinfertilitycases,56withrecurrentabo
4、rtioncasesand30healthywomenofchild-bearingagewereenrolledintheobservationandtheirdischargesamplesfromcervicalcanalweredetectedforUuandCTandanalyzedwithRT-PCR.ResultsThepositiverateofUu,CTandUu+CTinthegroupsofprimaryinfertility,secondinfertility,recurrentabortionandcontrolwere48.9%,44.3%,17.0%;52.4%,
5、47.6%,21.4%;51.8%,46.4%,19.7%and10.0%,6.7%,0.00%respectively.Comparedwiththecontrol.SignificantdifferenceswereobservedinpositiveratesofUuorCTorUu+CTineachgroupsofprimaryinfertility,secondinfertilityandrecurrentabortion(P<0.01or0.05);however,therewasnosignificantdifferenceamongthethreegroups.Aftertre
6、atment,19.3%、21.4%and23.2%ofpatientsinprimaryinfertility,secondinfertilityandrecurrentabortiongroupsweregivenbirthtobabies.ConclusionUuand/orCTinfectionarethemostimportantcausesleadingtoinfertilityandrecurrentabortion.Keywords：Infertility;Recurrentnaturalabortion;Ureaplasmaurealyicum;Chlamydiatracho
7、matis不孕症是妇科最常见疾病之一，发病率约为10%，且近年来有增加趋势。解脲支原体(UU)及沙眼衣原体(CT)作为性传播疾病的病原体，常侵犯男女泌尿生殖系统,引起感染,导致不孕、不育［1］。随着性意识的开放，上述病原体的感染率较过去明显升高。此外，UU及CT感染易导致反复自然流产，而引起不育［2］。UU和CT感染导致不孕不育,在国内外对此作专门调查研究仅有少数文献,并且有限的报告其感染率差异较
