幽门螺杆菌在冠心病发病中的作用及其机制探讨

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1、幽门螺杆菌在冠心病发病中的作用及其机制探讨青岛大学硕士学位论文幽门螺杆菌在冠心病发病中的作用及其机制探讨姓名龚洪涛申请学位级别硕士专业心血管内科学指导教师郭新贵20040301中文摘要幽门螺杆菌在冠心病发病中的作用及其机制探讨青岛大学医学院2001级内科心血管专业研究生龚洪涛导师郭新贵中文摘要C0baCter目的探讨幽门螺杆菌HeliPYl0riHp感染与ArterDiSeas冠心病C0r0narYYeCAD及其多种危险因素的关系迸一步了解HP感染在冠心病中的作用观察Hp感染对血管内皮功能脂质代谢炎症介质叶酸维生素BI及同型半胱氨酸的影响探讨其导致冠心病的发病机制方法应用酶联免疫吸

2、附实验法ELISA测定冠心病组242例包括稳定性心绞痛SAPl3例不稳定性心绞痛UAP例非冠心病组88例血清Hp抗体HPIgG比较两组HP感染率应用放射免疫法测定冠心病组242例前列环素IPGILl血栓素BTXBz内皮舒张因子N0白细胞介素一lBIB同型半胱氨酸HcY叶酸F01维生素B同时检测血录其高血压史糖尿病史吸烟史饮酒史年龄性别等对冠心病患者HPIgG阳性组与阴性组进行对比分析gG阳性率明显高于非冠心病组53．3％结果1冠心病组血清HPIVs平明显高于HPIgG阴性组P0．01而血浆PGF水平则明显低gG阳性组血浆gG阴性组P0．053冠心病患者HPI于HPI中文摘要HcgG

3、y浓度明显高于HPlgG阴性组P0．054冠心病患者HpIgG阴性组P0．05而两组血清TC阳性组HDLc明显低于HPlTGLDL5烟史饮酒史年龄性别无明显差别P0．0结论HP感染与冠心病发病有关它可降低患者血清HDLC及升高HCY水平从而促发冠心病HPIgG阳性组血浆TXB水平显著升高而PGF水平显著降低可能是其导致冠心病的发病机制之一关键词幽门螺杆菌感染冠心病危险因素同型半胱氨酸内皮功能英文摘要ofMechanismHelicobacterofContributionandPathogenicStudyInfectioninDiseaseCoronaryArteryPylori

4、AbstraettherelationsbetweenHelicobacterandinvestigate0hiectiveTowellastheeffectsofonendothelialdiseaseCADascoronaryarteryHpfunctionlipidBandmetabolismserum12thusfilrtherimmunologyfolateVitaminHomocysteine．AndtheofontheunderstandmechanisminfectionofCAD．HpprogressionthromboxaneMethodsHplgGELISAa

5、ndB2TXB2prostacyclin12PGl2NitrictotalOxideNOinterleukin·113IL-lcholesterolTCtriglycerideTGapolipoproteinAApoAapolipoproteinBApoBblooddensityfLDLbloodsugarwhitehighlipoproteinHDLlowdensitylipoprotein242of88cellmeasuredincaseswithoutCADascountWBCwereCADwithsubjectsriskwereinwastotalfactorsCADmea

6、suredinbothcontrolsandinquiredgroup．HplgG242withCADand88CADandcaseswithoutbetweenthesetwocomparedsubjectsweredatamentionedaboveandbetweengroups．AndexperimentalcomparedanalysedandintheCAD．HplgGpositivegroupHpIgGnegativegrouppatientsⅣimofforinCADisrateRelutes1111eseropositiveHplgGpatientssignifi

7、cantlyhigherofthanthattheofserumcasescontrols53．3％VSCADthe38．6％P0．05．2ForinlowerthanthatofHDLlevelisHpIgGseropositivegroupsignificantlyHpIgGintheserumlevelisoneP005andHplgOgroupseronegativeHcyseropositivethatthanofhigherHplgGseronegativ