芪仙安肠方治疗溃疡性结肠炎36例临床观察.doc

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1、芪仙安肠方治疗溃疡性结肠炎36例临床观察作者：田军彪刘建平单兆伟赵红伟康薇【摘要】　　目的观察芪仙安肠方治疗溃疡性结肠炎的临床疗效。方法将54例溃疡性结肠炎患者随机分为2组，治疗组36例予芪仙安肠方，日1剂，水煎400mL分2次口服；对照组18例予柳氮磺吡啶肠溶片，每次1g，每日3次口服。2组均1个月为1个疗程，2个疗程后统计疗效。观察2组治疗前后免疫球蛋白(Ig)A、IgG、IgM的变化以及治疗前后临床症状、体征的改善情况。结果治疗组总有效率91.67%，对照组总有效率77.77%，2组比较差异有统计学意义(P＜0.01)；2组治疗后临床症状、体征改善情况比较

2、差异均有统计学意义(P＜0.05)，治疗组优于对照组；治疗组治疗后IgA较治疗前显著下降，与治疗前比较差异有统计学意义(P＜0.01)，与对照组治疗后比较差异有统计学意义(P＜0.01)；2组治疗后IgG均下降，与治疗前比较差异均有统计学意义(P＜0.05，P＜0.01)，治疗组下降更为明显(P＜0.01)。结论芪仙安肠方治疗溃疡性结肠炎疗效确切。【关键词】结肠炎溃疡性中药疗法免疫球蛋白A免疫球蛋白G免疫球蛋白M　　ClinicalobservationonthetherapeuticeffectofQixiananchangdecoctionon36cases

3、ofulcerativecolitis　　【Abstract】ObjectiveToobservethetherapeuticeffectofQixiananchangdecoctiononulcerativecolitis.Methods54patientswithulcerativecolitisweredividedintotwogroups.36patientsintreatmentgroupweretreatedbyQixiananchangdecoction200mLeachtime,twiceaday,decoctedinwaterperos;18

4、patientsincontrolgroupweretreatedbySulfasalazine,1geachtime,3timesaday,withatreatmentcourseofonemonthforbothgroups.Thetherapeuticeffectswereevaluatedaftertwotreatmentcoursesinbothgroups,observingthevariationofIgA,IgG,IgMaswellasthedifferencesofclinicalsymptoms.ResultsThetotaleffectiv

5、erateintreatmentgroupwas91.67%,whichwas77.77%incontrolgroup，therewasasignificantdifferencebetweentwogroups(P<0.01).Therewassignificantdifferencesintheimprovementofclinicalsymptomsandsignsaftertreatmentbetweentwogroups(P<0.05),andtreatmentgroupwassuperiortothatofcontrolgroup.Aft

6、ertreatmentIgAintreatmentgroupwassignificantlydecreased,ascomparedwiththatbeforetreatment(P<0.01),andtherewassignificantdifferencesaftertreatmentbetweentwogroups(P<0.01).TheIgGinbothgroupwassignificantlyreducedaftertreatment,ascomparedwiththatbefore5treatment(P<0.05orP<0.

7、01),furthermore,thedecreaseintreatmentgroupwasmoreobviousthanthatofcontrolgroup(P<0.01).ConclusionQixiananchangdecoctioniseffectiveintreatmentonulcerativecolitis.　　【Keywords】Colitis;ulcerative;TCMtherapy;ImmunoglobulinA;ImmunoglobulinG　　溃疡性结肠炎是一种原因不明的非特异性炎症，病情顽固，常反复发作。2005-01—2007

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