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1、贝伐珠单抗联合CapeOx方案治疗晚期结直肠癌的Meta分析项良光1,2余海1叶建新2(通讯作者)【摘要】目的评价贝伐珠单抗联合CapeOx化疗方案治疗晚期结直肠癌的临床疗效和不良反应。方法检索PubMed、EMBASE>CENTRAL(Cochranecentralregisterofcontrolledtrials)、中国牛.物医学文献数据库(Chinesebiomedicalabstractdatabase,CBM)和中国期刊全文数据库(Chinanationalknowledgeinfrastructuredata
2、base,CNKI)和中国维普等数据库中关于災伐珠单抗联合CapeOx方案、冶疗晚期结直肠癌的随机对照试验(randomizedcontrolledtrial,RCT)文献，检索时间从建库到2015年3月31日。然后对这些文献进行筛选和质量评价，用RevMan4.2软件对符合标准的文献进行Meta分析。结果共纳入5项随机对照研究，共2459例晚期结直肠癌患者。合并后，OR=0.46(95%CI,0.38〜0.57)〉0。菱形完全位于垂直线的左侧。5篇文献中报道最多的是胃肠道功能紊乱、神经系统病变和手足综合症，其次还有粒细胞
3、减少等，但联合治疗组的不良反应发生率比单纯化疗组没有显著增加。结论贝伐珠单抗联合CapeOx方案化疗可以明显提高晚期结直肠癌患者的缓解率，而且不良反应发牛.率没有显著增加。【关键词】晚期结直肠癌；災伐珠单抗；CapeOx方案；随机对照试验；Meta分析AMeta-analysisofBevacizumabCombinedwithCapeOxregimenChemotherapyinTreatmentofAdvancedColorectalCancer.XiangLiang-guangl,2,YuHail,YeJian-xi
4、n2o1.DepartmentofGeneralSurgery,FuqingCityPeople’sHospital,FujianProvinceFuqing,350030;2.FirstAffiliatedHospitalofFujianMedicalUniversity,FujianProvinceFuzhou,350005)[Abstract]ObjectiveToevaluatetheclinicalefficacyandadverseeventsofbevacizumabcombinedwithCap
5、eOxregimenintreatingadvancedcolorectalcancer.MethodsReviewsfromrandomizedcontrolledclinicaltrials(RCTs)ofbevacizumabpluschemotherapeuticagentsforpatientswithadvancedcolorectalcancerfromthedatabasesofCochraneLibrary,Pubmed,EMBASE,CNKI,CBMandWanfangDatabaseforinvest
6、igatingsideeffectswereretrieved.Thenthemethodologicalqualityofincludedstudieswereevaluated.Meta-analysiswasperformedwiththeReviewManager4.2.ResultsItwasretrievedfiveoutof78eligiblepapersencompassing2459patients.Aftermerging,OR=0.46（95%Cl,0.38~0.57）〉0.Therhombusloc
7、atedintheleftofperpendicularline.Themostcommonadverseeventsincludedgastrointestinaldisorders,diarrhea,neurosensorytoxicityandhand-footsyndrome,aswellasgranulocytopenia.However,itexistednosignificantdifferencesbetweenCapeOxregimenplusbevacizumabgroupandaloneCapeOxr
8、egimengroup.ConclusionTheseresultsshowedTheefficacyofCapeOxregimenplusbevacizumabwassuperiortothatofaloneCapeOxregimen,buttheadverseeventsnotincreasedsi
