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1、出凝血四项及总胆汁酸联合检测对肝病患者的意义【摘要】 目的:分析出凝血四项及总胆汁酸随肝病患者的肝功能损害程度而变化的情况,并探讨联合检测出凝血四项及总胆汁酸的意义。方法:采用BeckmanLX20全自动生化分析仪对190例肝病患者及35例健康体检者的血清进行总胆汁酸(TBA)测定,同时用CoaDATA4001半自动血凝仪测定血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)及纤维蛋白原(FIB)水平并做相关统计学分析。结果:TBA在各型肝病中与正常对照组比较均有统计学意义(P<0.01),PT、APTT、TT、FIB四
2、项在急性肝炎、慢性轻度病毒性肝炎患者中与正常对照组比较差异无显著性(P>0.05),而在慢性中、重度肝炎、活动性肝硬化及重症肝病患者中与正常对照组比较差异有显著性(P<0.01)。结论:联合检测PT、APTT、TT、FIB及TBA能较好地反映肝功能状况并评估肝脏受损程度,可以从多方面为肝病的临床诊断提供客观准确的实验依据。【关键词】 总胆汁酸;凝血酶原时间;活化部分凝血活酶时间;凝血酶时间;纤维蛋白原 TheSignificanceoftheDeterminingJointlyFourItemsoftheNaturalBleedingandBlo
3、odCoagulationandtheTotalBileAcidinHepatopathyPatients LONGZhengrong TheCentralHospitalofHengyang,Hengyang,Hu’nan421001,China Abstract:ObjectiveToanalyzethesituationthatfouritemsofthenaturalbleedingandbloodcoagulationandthetotalbileacid(TBA)changewithhepatopathypatients,ex
4、tentofdamageofliverfunction,andtoexplorethesignificanceofthedeterminingjointlyfouritemsofthenaturalbleedingandbloodcoagulationandtheTBA.MethodsSerumTBAlevelsweredetectedwithBeckmanLX20in190casesofhepatopathypatientand35casesofhealthphysicalexamination(thenormalgroup)person,and
5、PlasmaPT,APTT,TTandthefibrinogen(FIB)levelsweredetectedwithCoaDATA4001semiautomaticcoagulationdetector,andtheresultsofthedifferentgroupswereanalyzedbyrelevantstatistics.ResultsThelevelsofTBAhadsignificantdifferencebetweenthehepatitisgroupandthenormalgroup,P<0.01.ThelevelsofPT,
6、APTT,TTandFIBintheacutehepatitis,chronicslighthepatitisandthenormalgrouphavenotaprominentdifference(P>0.05),andthoseinthechronicmezzohepatitis,serioushepatitis,hepatocirrhosisandheavyhepaticdiseasegroupshavemuchmoreprominentdifference(P<0.01)thanthenormalgroup.ConclusionTomeas
7、urejointlyPT,APTT,TT,FIBandTBAcangivetheliverfunctionstateandassesstheextentofdamageofliverwell,canofferaccurateexperimentbasisforclinicaldiagnosisofhepatopathyfrommanyaspects. Keywords:Totalbileacid;Prothrombintime;Activatedpartialthromboplastintime;Thrombintime;Fibrinogen
8、 肝脏是大多数凝血因子、凝血抑制剂和纤溶系统蛋白生成场所,也是许多已激活凝血因子和纤溶激活物的灭活之地,在凝血过程的各个